Soluble TNF-alpha-receptors I are prognostic markers in TIPS-treated patients with cirrhosis and portal hypertension.
<h4>Background</h4>TNFα levels are increased in liver cirrhosis even in the absence of infection, most likely owing to a continuous endotoxin influx into the portal blood. Soluble TNFα receptors (sTNFR type I and II) reflect release of the short-lived TNFα, because they are cleaved from...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/56144b5a1d10407fb08a34fc5399669d |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:56144b5a1d10407fb08a34fc5399669d |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:56144b5a1d10407fb08a34fc5399669d2021-11-18T08:40:22ZSoluble TNF-alpha-receptors I are prognostic markers in TIPS-treated patients with cirrhosis and portal hypertension.1932-620310.1371/journal.pone.0083341https://doaj.org/article/56144b5a1d10407fb08a34fc5399669d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24386183/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>TNFα levels are increased in liver cirrhosis even in the absence of infection, most likely owing to a continuous endotoxin influx into the portal blood. Soluble TNFα receptors (sTNFR type I and II) reflect release of the short-lived TNFα, because they are cleaved from the cells after binding of TNFα. The aims were to investigate the circulating levels of soluble TNFR-I and -II in cirrhotic patients receiving TIPS.<h4>Methods</h4>Forty-nine patients with liver cirrhosis and portal hypertension (12 viral, 37 alcoholic) received TIPS for prevention of re-bleeding (n = 14), therapy-refractory ascites (n = 20), or both (n = 15). Portal and hepatic venous blood was drawn in these patients during the TIPS procedure and during the control catheterization two weeks later. sTNFR-I and sTNFR-II were measured by ELISA, correlated to clinical and biochemical characteristics.<h4>Results</h4>Before TIPS insertion, sTNFR-II levels were lower in portal venous blood than in the hepatic venous blood, as well as in portal venous blood after TIPS insertion. No significant differences were measured in sTNFR-I levels. Hepatic venous levels of sTNFR-I above 4.5 ng/mL (p = 0.036) and sTNFR-II above 7 ng/mL (p = 0.05) after TIPS insertion were associated with decreased survival. A multivariate Cox-regression survival analysis identified the hepatic venous levels of sTNFR-I (p = 0.004) two weeks after TIPS, and Child score (p = 0.002) as independent predictors of mortality, while MELD-score was not.<h4>Conclusion</h4>Hepatic venous levels of sTNFR-I after TIPS insertion may predict mortality in patients with severe portal hypertension.Jonel TrebickaAleksander KragStefan GansweidPeter SchiedermaierHolger M StrunkRolf FimmersChristian P StrassburgFleming BendtsenSøren MøllerTilman SauerbruchUlrich SpenglerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83341 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Jonel Trebicka Aleksander Krag Stefan Gansweid Peter Schiedermaier Holger M Strunk Rolf Fimmers Christian P Strassburg Fleming Bendtsen Søren Møller Tilman Sauerbruch Ulrich Spengler Soluble TNF-alpha-receptors I are prognostic markers in TIPS-treated patients with cirrhosis and portal hypertension. |
| description |
<h4>Background</h4>TNFα levels are increased in liver cirrhosis even in the absence of infection, most likely owing to a continuous endotoxin influx into the portal blood. Soluble TNFα receptors (sTNFR type I and II) reflect release of the short-lived TNFα, because they are cleaved from the cells after binding of TNFα. The aims were to investigate the circulating levels of soluble TNFR-I and -II in cirrhotic patients receiving TIPS.<h4>Methods</h4>Forty-nine patients with liver cirrhosis and portal hypertension (12 viral, 37 alcoholic) received TIPS for prevention of re-bleeding (n = 14), therapy-refractory ascites (n = 20), or both (n = 15). Portal and hepatic venous blood was drawn in these patients during the TIPS procedure and during the control catheterization two weeks later. sTNFR-I and sTNFR-II were measured by ELISA, correlated to clinical and biochemical characteristics.<h4>Results</h4>Before TIPS insertion, sTNFR-II levels were lower in portal venous blood than in the hepatic venous blood, as well as in portal venous blood after TIPS insertion. No significant differences were measured in sTNFR-I levels. Hepatic venous levels of sTNFR-I above 4.5 ng/mL (p = 0.036) and sTNFR-II above 7 ng/mL (p = 0.05) after TIPS insertion were associated with decreased survival. A multivariate Cox-regression survival analysis identified the hepatic venous levels of sTNFR-I (p = 0.004) two weeks after TIPS, and Child score (p = 0.002) as independent predictors of mortality, while MELD-score was not.<h4>Conclusion</h4>Hepatic venous levels of sTNFR-I after TIPS insertion may predict mortality in patients with severe portal hypertension. |
| format |
article |
| author |
Jonel Trebicka Aleksander Krag Stefan Gansweid Peter Schiedermaier Holger M Strunk Rolf Fimmers Christian P Strassburg Fleming Bendtsen Søren Møller Tilman Sauerbruch Ulrich Spengler |
| author_facet |
Jonel Trebicka Aleksander Krag Stefan Gansweid Peter Schiedermaier Holger M Strunk Rolf Fimmers Christian P Strassburg Fleming Bendtsen Søren Møller Tilman Sauerbruch Ulrich Spengler |
| author_sort |
Jonel Trebicka |
| title |
Soluble TNF-alpha-receptors I are prognostic markers in TIPS-treated patients with cirrhosis and portal hypertension. |
| title_short |
Soluble TNF-alpha-receptors I are prognostic markers in TIPS-treated patients with cirrhosis and portal hypertension. |
| title_full |
Soluble TNF-alpha-receptors I are prognostic markers in TIPS-treated patients with cirrhosis and portal hypertension. |
| title_fullStr |
Soluble TNF-alpha-receptors I are prognostic markers in TIPS-treated patients with cirrhosis and portal hypertension. |
| title_full_unstemmed |
Soluble TNF-alpha-receptors I are prognostic markers in TIPS-treated patients with cirrhosis and portal hypertension. |
| title_sort |
soluble tnf-alpha-receptors i are prognostic markers in tips-treated patients with cirrhosis and portal hypertension. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/56144b5a1d10407fb08a34fc5399669d |
| work_keys_str_mv |
AT joneltrebicka solubletnfalphareceptorsiareprognosticmarkersintipstreatedpatientswithcirrhosisandportalhypertension AT aleksanderkrag solubletnfalphareceptorsiareprognosticmarkersintipstreatedpatientswithcirrhosisandportalhypertension AT stefangansweid solubletnfalphareceptorsiareprognosticmarkersintipstreatedpatientswithcirrhosisandportalhypertension AT peterschiedermaier solubletnfalphareceptorsiareprognosticmarkersintipstreatedpatientswithcirrhosisandportalhypertension AT holgermstrunk solubletnfalphareceptorsiareprognosticmarkersintipstreatedpatientswithcirrhosisandportalhypertension AT rolffimmers solubletnfalphareceptorsiareprognosticmarkersintipstreatedpatientswithcirrhosisandportalhypertension AT christianpstrassburg solubletnfalphareceptorsiareprognosticmarkersintipstreatedpatientswithcirrhosisandportalhypertension AT flemingbendtsen solubletnfalphareceptorsiareprognosticmarkersintipstreatedpatientswithcirrhosisandportalhypertension AT sørenmøller solubletnfalphareceptorsiareprognosticmarkersintipstreatedpatientswithcirrhosisandportalhypertension AT tilmansauerbruch solubletnfalphareceptorsiareprognosticmarkersintipstreatedpatientswithcirrhosisandportalhypertension AT ulrichspengler solubletnfalphareceptorsiareprognosticmarkersintipstreatedpatientswithcirrhosisandportalhypertension |
| _version_ |
1718421445749506048 |