The OSCAR-IB consensus criteria for retinal OCT quality assessment.

<h4>Background</h4>Retinal optical coherence tomography (OCT) is an imaging biomarker for neurodegeneration in multiple sclerosis (MS). In order to become validated as an outcome measure in multicenter studies, reliable quality control (QC) criteria with high inter-rater agreement are re...

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Autores principales:	Prejaas Tewarie, Lisanne Balk, Fiona Costello, Ari Green, Roland Martin, Sven Schippling, Axel Petzold
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56167ab7b592477496c8ad3f57c4a9bf
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spelling	oai:doaj.org-article:56167ab7b592477496c8ad3f57c4a9bf2021-11-18T07:21:38ZThe OSCAR-IB consensus criteria for retinal OCT quality assessment.1932-620310.1371/journal.pone.0034823https://doaj.org/article/56167ab7b592477496c8ad3f57c4a9bf2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22536333/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Retinal optical coherence tomography (OCT) is an imaging biomarker for neurodegeneration in multiple sclerosis (MS). In order to become validated as an outcome measure in multicenter studies, reliable quality control (QC) criteria with high inter-rater agreement are required.<h4>Methods/principal findings</h4>A prospective multicentre study on developing consensus QC criteria for retinal OCT in MS: (1) a literature review on OCT QC criteria; (2) application of these QC criteria to a training set of 101 retinal OCT scans from patients with MS; (3) kappa statistics for inter-rater agreement; (4) identification reasons for inter-rater disagreement; (5) development of new consensus QC criteria; (6) testing of the new QC criteria on the training set and (7) prospective validation on a new set of 159 OCT scans from patients with MS. The inter-rater agreement for acceptable scans among OCT readers (n = 3) was moderate (kappa 0·45) based on the non-validated QC criteria which were entirely based on the ophthalmological literature. A new set of QC criteria was developed based on recognition of: (O) obvious problems, (S) poor signal strength, (C) centration of scan, (A) algorithm failure, (R) retinal pathology other than MS related, (I) illumination and (B) beam placement. Adhering to these OSCAR-IB QC criteria increased the inter-rater agreement to kappa from moderate to substantial (0.61 training set and 0.61 prospective validation).<h4>Conclusions</h4>This study presents the first validated consensus QC criteria for retinal OCT reading in MS. The high inter-rater agreement suggests the OSCAR-IB QC criteria to be considered in the context of multicentre studies and trials in MS.Prejaas TewarieLisanne BalkFiona CostelloAri GreenRoland MartinSven SchipplingAxel PetzoldPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e34823 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Prejaas Tewarie Lisanne Balk Fiona Costello Ari Green Roland Martin Sven Schippling Axel Petzold The OSCAR-IB consensus criteria for retinal OCT quality assessment.
description	<h4>Background</h4>Retinal optical coherence tomography (OCT) is an imaging biomarker for neurodegeneration in multiple sclerosis (MS). In order to become validated as an outcome measure in multicenter studies, reliable quality control (QC) criteria with high inter-rater agreement are required.<h4>Methods/principal findings</h4>A prospective multicentre study on developing consensus QC criteria for retinal OCT in MS: (1) a literature review on OCT QC criteria; (2) application of these QC criteria to a training set of 101 retinal OCT scans from patients with MS; (3) kappa statistics for inter-rater agreement; (4) identification reasons for inter-rater disagreement; (5) development of new consensus QC criteria; (6) testing of the new QC criteria on the training set and (7) prospective validation on a new set of 159 OCT scans from patients with MS. The inter-rater agreement for acceptable scans among OCT readers (n = 3) was moderate (kappa 0·45) based on the non-validated QC criteria which were entirely based on the ophthalmological literature. A new set of QC criteria was developed based on recognition of: (O) obvious problems, (S) poor signal strength, (C) centration of scan, (A) algorithm failure, (R) retinal pathology other than MS related, (I) illumination and (B) beam placement. Adhering to these OSCAR-IB QC criteria increased the inter-rater agreement to kappa from moderate to substantial (0.61 training set and 0.61 prospective validation).<h4>Conclusions</h4>This study presents the first validated consensus QC criteria for retinal OCT reading in MS. The high inter-rater agreement suggests the OSCAR-IB QC criteria to be considered in the context of multicentre studies and trials in MS.
format	article
author	Prejaas Tewarie Lisanne Balk Fiona Costello Ari Green Roland Martin Sven Schippling Axel Petzold
author_facet	Prejaas Tewarie Lisanne Balk Fiona Costello Ari Green Roland Martin Sven Schippling Axel Petzold
author_sort	Prejaas Tewarie
title	The OSCAR-IB consensus criteria for retinal OCT quality assessment.
title_short	The OSCAR-IB consensus criteria for retinal OCT quality assessment.
title_full	The OSCAR-IB consensus criteria for retinal OCT quality assessment.
title_fullStr	The OSCAR-IB consensus criteria for retinal OCT quality assessment.
title_full_unstemmed	The OSCAR-IB consensus criteria for retinal OCT quality assessment.
title_sort	oscar-ib consensus criteria for retinal oct quality assessment.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/56167ab7b592477496c8ad3f57c4a9bf
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The OSCAR-IB consensus criteria for retinal OCT quality assessment.

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