Integral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters.

Modern techniques for estimating basal levels of electroactive neurotransmitters rely on the measurement of oxidative charges. This requires time integration of oxidation currents at certain intervals. Unfortunately, the selection of integration intervals relies on ad-hoc visual identification of pe...

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Autores principales:	Leonardo X Espín, Anders J Asp, James K Trevathan, Kip A Ludwig, J Luis Lujan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5617351dee4d4832a532559318bb2121
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spelling	oai:doaj.org-article:5617351dee4d4832a532559318bb21212021-12-02T20:04:51ZIntegral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters.1932-620310.1371/journal.pone.0254594https://doaj.org/article/5617351dee4d4832a532559318bb21212021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254594https://doaj.org/toc/1932-6203Modern techniques for estimating basal levels of electroactive neurotransmitters rely on the measurement of oxidative charges. This requires time integration of oxidation currents at certain intervals. Unfortunately, the selection of integration intervals relies on ad-hoc visual identification of peaks on the oxidation currents, which introduces sources of error and precludes the development of automated procedures necessary for analysis and quantification of neurotransmitter levels in large data sets. In an effort to improve charge quantification techniques, here we present novel methods for automatic selection of integration boundaries. Our results show that these methods allow quantification of oxidation reactions both in vitro and in vivo and of multiple analytes in vitro.Leonardo X EspínAnders J AspJames K TrevathanKip A LudwigJ Luis LujanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254594 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leonardo X Espín Anders J Asp James K Trevathan Kip A Ludwig J Luis Lujan Integral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters.
description	Modern techniques for estimating basal levels of electroactive neurotransmitters rely on the measurement of oxidative charges. This requires time integration of oxidation currents at certain intervals. Unfortunately, the selection of integration intervals relies on ad-hoc visual identification of peaks on the oxidation currents, which introduces sources of error and precludes the development of automated procedures necessary for analysis and quantification of neurotransmitter levels in large data sets. In an effort to improve charge quantification techniques, here we present novel methods for automatic selection of integration boundaries. Our results show that these methods allow quantification of oxidation reactions both in vitro and in vivo and of multiple analytes in vitro.
format	article
author	Leonardo X Espín Anders J Asp James K Trevathan Kip A Ludwig J Luis Lujan
author_facet	Leonardo X Espín Anders J Asp James K Trevathan Kip A Ludwig J Luis Lujan
author_sort	Leonardo X Espín
title	Integral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters.
title_short	Integral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters.
title_full	Integral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters.
title_fullStr	Integral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters.
title_full_unstemmed	Integral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters.
title_sort	integral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5617351dee4d4832a532559318bb2121
work_keys_str_mv	AT leonardoxespin integralmethodsforautomaticquantificationoffastscancyclicvoltammetrydetectedneurotransmitters AT andersjasp integralmethodsforautomaticquantificationoffastscancyclicvoltammetrydetectedneurotransmitters AT jamesktrevathan integralmethodsforautomaticquantificationoffastscancyclicvoltammetrydetectedneurotransmitters AT kipaludwig integralmethodsforautomaticquantificationoffastscancyclicvoltammetrydetectedneurotransmitters AT jluislujan integralmethodsforautomaticquantificationoffastscancyclicvoltammetrydetectedneurotransmitters
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Integral methods for automatic quantification of fast-scan-cyclic-voltammetry detected neurotransmitters.

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