Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis

The pancreas arises from a small population of cells but how individual cells contribute to organ formation is unclear. Here, the authors deconstruct pancreas organogenesis into clonal units, showing that single progenitors give rise to heterogeneous multi-lineage and endocrinogenic single-lineage c...

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Autores principales:	Hjalte List Larsen, Laura Martín-Coll, Alexander Valentin Nielsen, Christopher V. E. Wright, Ala Trusina, Yung Hae Kim, Anne Grapin-Botton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5617ac1576cd4daf93bca36ae542b223
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spelling	oai:doaj.org-article:5617ac1576cd4daf93bca36ae542b2232021-12-02T14:40:36ZStochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis10.1038/s41467-017-00258-42041-1723https://doaj.org/article/5617ac1576cd4daf93bca36ae542b2232017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00258-4https://doaj.org/toc/2041-1723The pancreas arises from a small population of cells but how individual cells contribute to organ formation is unclear. Here, the authors deconstruct pancreas organogenesis into clonal units, showing that single progenitors give rise to heterogeneous multi-lineage and endocrinogenic single-lineage clones.Hjalte List LarsenLaura Martín-CollAlexander Valentin NielsenChristopher V. E. WrightAla TrusinaYung Hae KimAnne Grapin-BottonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hjalte List Larsen Laura Martín-Coll Alexander Valentin Nielsen Christopher V. E. Wright Ala Trusina Yung Hae Kim Anne Grapin-Botton Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis
description	The pancreas arises from a small population of cells but how individual cells contribute to organ formation is unclear. Here, the authors deconstruct pancreas organogenesis into clonal units, showing that single progenitors give rise to heterogeneous multi-lineage and endocrinogenic single-lineage clones.
format	article
author	Hjalte List Larsen Laura Martín-Coll Alexander Valentin Nielsen Christopher V. E. Wright Ala Trusina Yung Hae Kim Anne Grapin-Botton
author_facet	Hjalte List Larsen Laura Martín-Coll Alexander Valentin Nielsen Christopher V. E. Wright Ala Trusina Yung Hae Kim Anne Grapin-Botton
author_sort	Hjalte List Larsen
title	Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis
title_short	Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis
title_full	Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis
title_fullStr	Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis
title_full_unstemmed	Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis
title_sort	stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5617ac1576cd4daf93bca36ae542b223
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Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis

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