Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis

The pancreas arises from a small population of cells but how individual cells contribute to organ formation is unclear. Here, the authors deconstruct pancreas organogenesis into clonal units, showing that single progenitors give rise to heterogeneous multi-lineage and endocrinogenic single-lineage c...

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Autores principales: Hjalte List Larsen, Laura Martín-Coll, Alexander Valentin Nielsen, Christopher V. E. Wright, Ala Trusina, Yung Hae Kim, Anne Grapin-Botton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5617ac1576cd4daf93bca36ae542b223
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