A bioimpedance-based monitor for real-time detection and identification of secondary brain injury

Abstract Secondary brain injury impacts patient prognosis and can lead to long-term morbidity and mortality in cases of trauma. Continuous monitoring of secondary injury in acute clinical settings is primarily limited to intracranial pressure (ICP); however, ICP is unable to identify essential under...

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Autores principales:	Alicia Everitt, Brandon Root, Daniel Calnan, Preston Manwaring, David Bauer, Ryan Halter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5619373cbb944853863f19f40dd26f7c
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spelling	oai:doaj.org-article:5619373cbb944853863f19f40dd26f7c2021-12-02T16:31:02ZA bioimpedance-based monitor for real-time detection and identification of secondary brain injury10.1038/s41598-021-94600-y2045-2322https://doaj.org/article/5619373cbb944853863f19f40dd26f7c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94600-yhttps://doaj.org/toc/2045-2322Abstract Secondary brain injury impacts patient prognosis and can lead to long-term morbidity and mortality in cases of trauma. Continuous monitoring of secondary injury in acute clinical settings is primarily limited to intracranial pressure (ICP); however, ICP is unable to identify essential underlying etiologies of injury needed to guide treatment (e.g. immediate surgical intervention vs medical management). Here we show that a novel intracranial bioimpedance monitor (BIM) can detect onset of secondary injury, differentiate focal (e.g. hemorrhage) from global (e.g. edema) events, identify underlying etiology and provide localization of an intracranial mass effect. We found in an in vivo porcine model that the BIM detected changes in intracranial volume down to 0.38 mL, differentiated high impedance (e.g. ischemic) from low impedance (e.g. hemorrhagic) injuries (p < 0.001), separated focal from global events (p < 0.001) and provided coarse ‘imaging’ through localization of the mass effect. This work presents for the first time the full design, development, characterization and successful implementation of an intracranial bioimpedance monitor. This BIM technology could be further translated to clinical pathologies including but not limited to traumatic brain injury, intracerebral hemorrhage, stroke, hydrocephalus and post-surgical monitoring.Alicia EverittBrandon RootDaniel CalnanPreston ManwaringDavid BauerRyan HalterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alicia Everitt Brandon Root Daniel Calnan Preston Manwaring David Bauer Ryan Halter A bioimpedance-based monitor for real-time detection and identification of secondary brain injury
description	Abstract Secondary brain injury impacts patient prognosis and can lead to long-term morbidity and mortality in cases of trauma. Continuous monitoring of secondary injury in acute clinical settings is primarily limited to intracranial pressure (ICP); however, ICP is unable to identify essential underlying etiologies of injury needed to guide treatment (e.g. immediate surgical intervention vs medical management). Here we show that a novel intracranial bioimpedance monitor (BIM) can detect onset of secondary injury, differentiate focal (e.g. hemorrhage) from global (e.g. edema) events, identify underlying etiology and provide localization of an intracranial mass effect. We found in an in vivo porcine model that the BIM detected changes in intracranial volume down to 0.38 mL, differentiated high impedance (e.g. ischemic) from low impedance (e.g. hemorrhagic) injuries (p < 0.001), separated focal from global events (p < 0.001) and provided coarse ‘imaging’ through localization of the mass effect. This work presents for the first time the full design, development, characterization and successful implementation of an intracranial bioimpedance monitor. This BIM technology could be further translated to clinical pathologies including but not limited to traumatic brain injury, intracerebral hemorrhage, stroke, hydrocephalus and post-surgical monitoring.
format	article
author	Alicia Everitt Brandon Root Daniel Calnan Preston Manwaring David Bauer Ryan Halter
author_facet	Alicia Everitt Brandon Root Daniel Calnan Preston Manwaring David Bauer Ryan Halter
author_sort	Alicia Everitt
title	A bioimpedance-based monitor for real-time detection and identification of secondary brain injury
title_short	A bioimpedance-based monitor for real-time detection and identification of secondary brain injury
title_full	A bioimpedance-based monitor for real-time detection and identification of secondary brain injury
title_fullStr	A bioimpedance-based monitor for real-time detection and identification of secondary brain injury
title_full_unstemmed	A bioimpedance-based monitor for real-time detection and identification of secondary brain injury
title_sort	bioimpedance-based monitor for real-time detection and identification of secondary brain injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5619373cbb944853863f19f40dd26f7c
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A bioimpedance-based monitor for real-time detection and identification of secondary brain injury

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