Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures

The network mechanism supporting seizure spread in temporal lobe epilepsy (TLE) is only partially understood. Using optogenetic methods, Lu et al.identify a feed-forward propagation pathway of ictal discharges from the dentate gyrus/hilus to the medial entorhinal cortex in a mouse model of TLE.

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Autores principales:	Yi Lu, Cheng Zhong, Lulu Wang, Pengfei Wei, Wei He, Kang Huang, Yi Zhang, Yang Zhan, Guoping Feng, Liping Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/561ad0075d1a4e4a861ac33f7a9dd9e4
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spelling	oai:doaj.org-article:561ad0075d1a4e4a861ac33f7a9dd9e42021-12-02T16:56:47ZOptogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures10.1038/ncomms109622041-1723https://doaj.org/article/561ad0075d1a4e4a861ac33f7a9dd9e42016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10962https://doaj.org/toc/2041-1723The network mechanism supporting seizure spread in temporal lobe epilepsy (TLE) is only partially understood. Using optogenetic methods, Lu et al.identify a feed-forward propagation pathway of ictal discharges from the dentate gyrus/hilus to the medial entorhinal cortex in a mouse model of TLE.Yi LuCheng ZhongLulu WangPengfei WeiWei HeKang HuangYi ZhangYang ZhanGuoping FengLiping WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Lu Cheng Zhong Lulu Wang Pengfei Wei Wei He Kang Huang Yi Zhang Yang Zhan Guoping Feng Liping Wang Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures
description	The network mechanism supporting seizure spread in temporal lobe epilepsy (TLE) is only partially understood. Using optogenetic methods, Lu et al.identify a feed-forward propagation pathway of ictal discharges from the dentate gyrus/hilus to the medial entorhinal cortex in a mouse model of TLE.
format	article
author	Yi Lu Cheng Zhong Lulu Wang Pengfei Wei Wei He Kang Huang Yi Zhang Yang Zhan Guoping Feng Liping Wang
author_facet	Yi Lu Cheng Zhong Lulu Wang Pengfei Wei Wei He Kang Huang Yi Zhang Yang Zhan Guoping Feng Liping Wang
author_sort	Yi Lu
title	Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures
title_short	Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures
title_full	Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures
title_fullStr	Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures
title_full_unstemmed	Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures
title_sort	optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/561ad0075d1a4e4a861ac33f7a9dd9e4
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Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures

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