Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures

The network mechanism supporting seizure spread in temporal lobe epilepsy (TLE) is only partially understood. Using optogenetic methods, Lu et al.identify a feed-forward propagation pathway of ictal discharges from the dentate gyrus/hilus to the medial entorhinal cortex in a mouse model of TLE.

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Auteurs principaux: Yi Lu, Cheng Zhong, Lulu Wang, Pengfei Wei, Wei He, Kang Huang, Yi Zhang, Yang Zhan, Guoping Feng, Liping Wang
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/561ad0075d1a4e4a861ac33f7a9dd9e4
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