New liquid oral formulations of hydroxychloroquine: a physicochemical stability study

Hydroxychloroquine (HCQ) presents many drug properties that increase its therapeutic use. There are, indeed, different research pathways in numerous autoimmune, inflammatory, and infectious diseases, as well as in cancerology. HCQ is only marketed as HCQ sulfate in film-coated or coated tablets for...

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Autores principales:	Lebreton Vincent, Bourcier Blandine, Cosson Karine, Lagarce Frédéric, Spiesser-Robelet Laurence, Vrignaud Sandy
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	an antimalarial agent hplc hydroxychloroquine sulfate oral suspension stability study Therapeutics. Pharmacology RM1-950 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/561c3cf312b54639b970bc2690cacafe
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id	oai:doaj.org-article:561c3cf312b54639b970bc2690cacafe
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spelling	oai:doaj.org-article:561c3cf312b54639b970bc2690cacafe2021-12-05T14:11:02ZNew liquid oral formulations of hydroxychloroquine: a physicochemical stability study2365-24112365-242X10.1515/pthp-2020-0013https://doaj.org/article/561c3cf312b54639b970bc2690cacafe2021-03-01T00:00:00Zhttps://doi.org/10.1515/pthp-2020-0013https://doaj.org/toc/2365-2411https://doaj.org/toc/2365-242XHydroxychloroquine (HCQ) presents many drug properties that increase its therapeutic use. There are, indeed, different research pathways in numerous autoimmune, inflammatory, and infectious diseases, as well as in cancerology. HCQ is only marketed as HCQ sulfate in film-coated or coated tablets for oral use. No pediatric liquid form is currently available on the market. The purpose of the present study is to develop oral liquid formulations for HCQ at 50 mg/mL with two different oral vehicle suspensions, namely ORA-Plus®/ORA-Sweet® (ORA) and Syrspend® SF PH 4 (SYR).Lebreton VincentBourcier BlandineCosson KarineLagarce FrédéricSpiesser-Robelet LaurenceVrignaud SandyDe Gruyterarticlean antimalarial agenthplchydroxychloroquine sulfateoral suspensionstability studyTherapeutics. PharmacologyRM1-950Pharmaceutical industryHD9665-9675ENPharmaceutical Technology in Hospital Pharmacy, Vol 6, Iss 1, Pp 459-67 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	an antimalarial agent hplc hydroxychloroquine sulfate oral suspension stability study Therapeutics. Pharmacology RM1-950 Pharmaceutical industry HD9665-9675
spellingShingle	an antimalarial agent hplc hydroxychloroquine sulfate oral suspension stability study Therapeutics. Pharmacology RM1-950 Pharmaceutical industry HD9665-9675 Lebreton Vincent Bourcier Blandine Cosson Karine Lagarce Frédéric Spiesser-Robelet Laurence Vrignaud Sandy New liquid oral formulations of hydroxychloroquine: a physicochemical stability study
description	Hydroxychloroquine (HCQ) presents many drug properties that increase its therapeutic use. There are, indeed, different research pathways in numerous autoimmune, inflammatory, and infectious diseases, as well as in cancerology. HCQ is only marketed as HCQ sulfate in film-coated or coated tablets for oral use. No pediatric liquid form is currently available on the market. The purpose of the present study is to develop oral liquid formulations for HCQ at 50 mg/mL with two different oral vehicle suspensions, namely ORA-Plus®/ORA-Sweet® (ORA) and Syrspend® SF PH 4 (SYR).
format	article
author	Lebreton Vincent Bourcier Blandine Cosson Karine Lagarce Frédéric Spiesser-Robelet Laurence Vrignaud Sandy
author_facet	Lebreton Vincent Bourcier Blandine Cosson Karine Lagarce Frédéric Spiesser-Robelet Laurence Vrignaud Sandy
author_sort	Lebreton Vincent
title	New liquid oral formulations of hydroxychloroquine: a physicochemical stability study
title_short	New liquid oral formulations of hydroxychloroquine: a physicochemical stability study
title_full	New liquid oral formulations of hydroxychloroquine: a physicochemical stability study
title_fullStr	New liquid oral formulations of hydroxychloroquine: a physicochemical stability study
title_full_unstemmed	New liquid oral formulations of hydroxychloroquine: a physicochemical stability study
title_sort	new liquid oral formulations of hydroxychloroquine: a physicochemical stability study
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/561c3cf312b54639b970bc2690cacafe
work_keys_str_mv	AT lebretonvincent newliquidoralformulationsofhydroxychloroquineaphysicochemicalstabilitystudy AT bourcierblandine newliquidoralformulationsofhydroxychloroquineaphysicochemicalstabilitystudy AT cossonkarine newliquidoralformulationsofhydroxychloroquineaphysicochemicalstabilitystudy AT lagarcefrederic newliquidoralformulationsofhydroxychloroquineaphysicochemicalstabilitystudy AT spiesserrobeletlaurence newliquidoralformulationsofhydroxychloroquineaphysicochemicalstabilitystudy AT vrignaudsandy newliquidoralformulationsofhydroxychloroquineaphysicochemicalstabilitystudy
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New liquid oral formulations of hydroxychloroquine: a physicochemical stability study

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