A randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder

Abstract Attention-deficit/hyperactivity disorder (ADHD) is a childhood onset disorder persisting into adulthood for a large proportion of cases. Neurofeedback (NF) has shown promising results in children with ADHD, but randomized controlled trials in adults with ADHD are scarce. We aimed to compare...

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Autores principales:	Beatrix Barth, Kerstin Mayer-Carius, Ute Strehl, Sarah N. Wyckoff, Florian B. Haeussinger, Andreas J. Fallgatter, Ann-Christine Ehlis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/561d67aa496548ceb05a1dbd91573d79
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spelling	oai:doaj.org-article:561d67aa496548ceb05a1dbd91573d792021-12-02T16:45:40ZA randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder10.1038/s41598-021-95928-12045-2322https://doaj.org/article/561d67aa496548ceb05a1dbd91573d792021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95928-1https://doaj.org/toc/2045-2322Abstract Attention-deficit/hyperactivity disorder (ADHD) is a childhood onset disorder persisting into adulthood for a large proportion of cases. Neurofeedback (NF) has shown promising results in children with ADHD, but randomized controlled trials in adults with ADHD are scarce. We aimed to compare slow cortical potential (SCP)- and functional near-infrared spectroscopy (fNIRS) NF to a semi-active electromyography biofeedback (EMG-BF) control condition regarding changes in symptoms and the impact of learning success, as well as changes in neurophysiological parameters in an adult ADHD population. Patients were randomly assigned to SCP-NF (n = 26), fNIRS-NF (n = 21) or EMG-BF (n = 20). Outcome parameters were assessed over 30 training sessions (pre, intermediate, post) and at 6-months follow-up (FU) including 3 booster sessions. EEG was recorded during two auditory Go/NoGo paradigms assessing the P300 and contingent negative variation (CNV). fNIRS measurements were conducted during an n-back- as well as a Go/NoGo task. All three groups showed equally significant symptom improvements suggesting placebo- or non-specific effects on the primary outcome measure. Only when differentiating between learners and non-learners, fNIRS learners displayed stronger reduction of ADHD global scores compared to SCP non-learners at FU, and fNIRS learners showed specifically low impulsivity ratings. 30.8% in the SCP-NF and 61.9% of participants in the fNIRS-NF learned to regulate the respective NF target parameter. We conclude that some adults with ADHD learn to regulate SCP amplitudes and especially prefrontal hemodynamic activity during NF. We did not find any significant differences in outcome between groups when looking at the whole sample. When evaluating learners only, they demonstrate superior effects as compared to non-learners, which suggests specific effects in addition to non-specific effects of NF when learning occurs.Beatrix BarthKerstin Mayer-CariusUte StrehlSarah N. WyckoffFlorian B. HaeussingerAndreas J. FallgatterAnn-Christine EhlisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Beatrix Barth Kerstin Mayer-Carius Ute Strehl Sarah N. Wyckoff Florian B. Haeussinger Andreas J. Fallgatter Ann-Christine Ehlis A randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder
description	Abstract Attention-deficit/hyperactivity disorder (ADHD) is a childhood onset disorder persisting into adulthood for a large proportion of cases. Neurofeedback (NF) has shown promising results in children with ADHD, but randomized controlled trials in adults with ADHD are scarce. We aimed to compare slow cortical potential (SCP)- and functional near-infrared spectroscopy (fNIRS) NF to a semi-active electromyography biofeedback (EMG-BF) control condition regarding changes in symptoms and the impact of learning success, as well as changes in neurophysiological parameters in an adult ADHD population. Patients were randomly assigned to SCP-NF (n = 26), fNIRS-NF (n = 21) or EMG-BF (n = 20). Outcome parameters were assessed over 30 training sessions (pre, intermediate, post) and at 6-months follow-up (FU) including 3 booster sessions. EEG was recorded during two auditory Go/NoGo paradigms assessing the P300 and contingent negative variation (CNV). fNIRS measurements were conducted during an n-back- as well as a Go/NoGo task. All three groups showed equally significant symptom improvements suggesting placebo- or non-specific effects on the primary outcome measure. Only when differentiating between learners and non-learners, fNIRS learners displayed stronger reduction of ADHD global scores compared to SCP non-learners at FU, and fNIRS learners showed specifically low impulsivity ratings. 30.8% in the SCP-NF and 61.9% of participants in the fNIRS-NF learned to regulate the respective NF target parameter. We conclude that some adults with ADHD learn to regulate SCP amplitudes and especially prefrontal hemodynamic activity during NF. We did not find any significant differences in outcome between groups when looking at the whole sample. When evaluating learners only, they demonstrate superior effects as compared to non-learners, which suggests specific effects in addition to non-specific effects of NF when learning occurs.
format	article
author	Beatrix Barth Kerstin Mayer-Carius Ute Strehl Sarah N. Wyckoff Florian B. Haeussinger Andreas J. Fallgatter Ann-Christine Ehlis
author_facet	Beatrix Barth Kerstin Mayer-Carius Ute Strehl Sarah N. Wyckoff Florian B. Haeussinger Andreas J. Fallgatter Ann-Christine Ehlis
author_sort	Beatrix Barth
title	A randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder
title_short	A randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder
title_full	A randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder
title_fullStr	A randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder
title_full_unstemmed	A randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder
title_sort	randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/561d67aa496548ceb05a1dbd91573d79
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A randomized-controlled neurofeedback trial in adult attention-deficit/hyperactivity disorder

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