Association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk

Abstract Background/objective Changes in metabolism and extensive hemodynamic adjustments occur during normal pregnancy. The presence of maternal obesity imposes an overload to these physiological adaptations that may result in increased risk for the development of cardiometabolic complications duri...

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Autores principales:	Luz Isabel Omaña-Guzmán, Luis Ortiz-Hernández, Mónica Ancira-Moreno, Vanesa Morales-Hernández, Marie S. O’Neill, Felipe Vadillo-Ortega
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/561fb7631c6245c68df0837cb94fff21
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spelling	oai:doaj.org-article:561fb7631c6245c68df0837cb94fff212021-11-28T12:22:31ZAssociation of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk10.1038/s41387-021-00178-92044-4052https://doaj.org/article/561fb7631c6245c68df0837cb94fff212021-11-01T00:00:00Zhttps://doi.org/10.1038/s41387-021-00178-9https://doaj.org/toc/2044-4052Abstract Background/objective Changes in metabolism and extensive hemodynamic adjustments occur during normal pregnancy. The presence of maternal obesity imposes an overload to these physiological adaptations that may result in increased risk for the development of cardiometabolic complications during and after pregnancy. The aim of this study is to describe total cholesterol (TC), triglycerides (TG), glucose, and arterial blood pressure (BP) trajectories and to analyze the association of these cardiometabolic risk indicators during pregnancy with pre-pregnancy body mass index (pBMI) and monthly gestational weight gain (MGWG). Subjects/methods A prospective cohort study of pregnant women was conducted in Mexico City. Monthly samples of blood were taken during clinical follow-up and biochemical and blood pressure were measured during each visit. Adjusted linear mixed-effect regression models were fit to describe the trajectories of these biomarkers during pregnancy and to analyze the association with pBMI and MGWG. Results Seven hundred and twenty women were included of which 16.6% had pre-gestational obesity, 33.2% had pre-gestational overweight, 45.8% had normal pBMI and 4.4% had pre-gestational underweight. Women with pre-gestational obesity had higher lipids concentrations in the beginning of pregnancy (TC: $$\hat \beta$$ β ̂ = 33.08, p = 0.010; TG: $$\hat \beta$$ β ̂ = 31.29, p = <0.001) but the concentrations increased less than in women with normal pBMI (TC: $$\hat \beta$$ β ̂ = −14.18, p = 0.001; TG: $$\hat \beta$$ β ̂ = −5.42, p < 0.001). By the end of pregnancy, women with pre-gestational obesity had lower concentrations of lipids than women with normal pBMI. By contrast, women with pre-gestational obesity had higher glucose concentrations and higher BP levels than women with normal pBMI over pregnancy. Conclusions pBMI is differentially associated with longitudinal trajectories of maternal biochemical markers of cardiometabolic risk. MGWG did not significantly affect the biochemical indicators or BP trajectories. Our results suggest that pBMI is more relevant to predicting adverse cardiometabolic markers trajectories during pregnancy than MGWG.Luz Isabel Omaña-GuzmánLuis Ortiz-HernándezMónica Ancira-MorenoVanesa Morales-HernándezMarie S. O’NeillFelipe Vadillo-OrtegaNature Publishing GrouparticleNutritional diseases. Deficiency diseasesRC620-627ENNutrition & Diabetes, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Nutritional diseases. Deficiency diseases RC620-627 Luz Isabel Omaña-Guzmán Luis Ortiz-Hernández Mónica Ancira-Moreno Vanesa Morales-Hernández Marie S. O’Neill Felipe Vadillo-Ortega Association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk
description	Abstract Background/objective Changes in metabolism and extensive hemodynamic adjustments occur during normal pregnancy. The presence of maternal obesity imposes an overload to these physiological adaptations that may result in increased risk for the development of cardiometabolic complications during and after pregnancy. The aim of this study is to describe total cholesterol (TC), triglycerides (TG), glucose, and arterial blood pressure (BP) trajectories and to analyze the association of these cardiometabolic risk indicators during pregnancy with pre-pregnancy body mass index (pBMI) and monthly gestational weight gain (MGWG). Subjects/methods A prospective cohort study of pregnant women was conducted in Mexico City. Monthly samples of blood were taken during clinical follow-up and biochemical and blood pressure were measured during each visit. Adjusted linear mixed-effect regression models were fit to describe the trajectories of these biomarkers during pregnancy and to analyze the association with pBMI and MGWG. Results Seven hundred and twenty women were included of which 16.6% had pre-gestational obesity, 33.2% had pre-gestational overweight, 45.8% had normal pBMI and 4.4% had pre-gestational underweight. Women with pre-gestational obesity had higher lipids concentrations in the beginning of pregnancy (TC: $$\hat \beta$$ β ̂ = 33.08, p = 0.010; TG: $$\hat \beta$$ β ̂ = 31.29, p = <0.001) but the concentrations increased less than in women with normal pBMI (TC: $$\hat \beta$$ β ̂ = −14.18, p = 0.001; TG: $$\hat \beta$$ β ̂ = −5.42, p < 0.001). By the end of pregnancy, women with pre-gestational obesity had lower concentrations of lipids than women with normal pBMI. By contrast, women with pre-gestational obesity had higher glucose concentrations and higher BP levels than women with normal pBMI over pregnancy. Conclusions pBMI is differentially associated with longitudinal trajectories of maternal biochemical markers of cardiometabolic risk. MGWG did not significantly affect the biochemical indicators or BP trajectories. Our results suggest that pBMI is more relevant to predicting adverse cardiometabolic markers trajectories during pregnancy than MGWG.
format	article
author	Luz Isabel Omaña-Guzmán Luis Ortiz-Hernández Mónica Ancira-Moreno Vanesa Morales-Hernández Marie S. O’Neill Felipe Vadillo-Ortega
author_facet	Luz Isabel Omaña-Guzmán Luis Ortiz-Hernández Mónica Ancira-Moreno Vanesa Morales-Hernández Marie S. O’Neill Felipe Vadillo-Ortega
author_sort	Luz Isabel Omaña-Guzmán
title	Association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk
title_short	Association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk
title_full	Association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk
title_fullStr	Association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk
title_full_unstemmed	Association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk
title_sort	association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/561fb7631c6245c68df0837cb94fff21
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Association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk

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