Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy

Abstract We explored regional functional connectivity alterations in intractable focal epilepsy brains using resting-state functional MRI. Distributions of the network parameters (corresponding to degree and eigenvector centrality) measured at each brain region for all 25 patients were significantly...

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Autores principales:	Yasuo Nakai, Hiroki Nishibayashi, Tomohiro Donishi, Masaki Terada, Naoyuki Nakao, Yoshiki Kaneoke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/562016b5c2f0404fb94ce2ecee01b60d
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spelling	oai:doaj.org-article:562016b5c2f0404fb94ce2ecee01b60d2021-12-02T14:01:24ZRegional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy10.1038/s41598-021-81207-62045-2322https://doaj.org/article/562016b5c2f0404fb94ce2ecee01b60d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81207-6https://doaj.org/toc/2045-2322Abstract We explored regional functional connectivity alterations in intractable focal epilepsy brains using resting-state functional MRI. Distributions of the network parameters (corresponding to degree and eigenvector centrality) measured at each brain region for all 25 patients were significantly different from age- and sex-matched control data that were estimated by a healthy control dataset (n = 582, 18–84 years old). The number of abnormal regions whose parameters exceeded the mean + 2 SD of age- and sex-matched data for each patient were associated with various clinical parameters such as the duration of illness and seizure severity. Furthermore, abnormal regions for each patient tended to have functional connections with each other (mean ± SD = 58.6 ± 20.2%), the magnitude of which was negatively related to the quality of life. The abnormal regions distributed within the default mode network with significantly higher probability (p < 0.05) in 7 of 25 patients. We consider that the detection of abnormal regions by functional connectivity analysis using a large number of control datasets is useful for the numerical assessment of each patient’s clinical conditions, although further study is necessary to elucidate etiology-specific abnormalities.Yasuo NakaiHiroki NishibayashiTomohiro DonishiMasaki TeradaNaoyuki NakaoYoshiki KaneokeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yasuo Nakai Hiroki Nishibayashi Tomohiro Donishi Masaki Terada Naoyuki Nakao Yoshiki Kaneoke Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy
description	Abstract We explored regional functional connectivity alterations in intractable focal epilepsy brains using resting-state functional MRI. Distributions of the network parameters (corresponding to degree and eigenvector centrality) measured at each brain region for all 25 patients were significantly different from age- and sex-matched control data that were estimated by a healthy control dataset (n = 582, 18–84 years old). The number of abnormal regions whose parameters exceeded the mean + 2 SD of age- and sex-matched data for each patient were associated with various clinical parameters such as the duration of illness and seizure severity. Furthermore, abnormal regions for each patient tended to have functional connections with each other (mean ± SD = 58.6 ± 20.2%), the magnitude of which was negatively related to the quality of life. The abnormal regions distributed within the default mode network with significantly higher probability (p < 0.05) in 7 of 25 patients. We consider that the detection of abnormal regions by functional connectivity analysis using a large number of control datasets is useful for the numerical assessment of each patient’s clinical conditions, although further study is necessary to elucidate etiology-specific abnormalities.
format	article
author	Yasuo Nakai Hiroki Nishibayashi Tomohiro Donishi Masaki Terada Naoyuki Nakao Yoshiki Kaneoke
author_facet	Yasuo Nakai Hiroki Nishibayashi Tomohiro Donishi Masaki Terada Naoyuki Nakao Yoshiki Kaneoke
author_sort	Yasuo Nakai
title	Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy
title_short	Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy
title_full	Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy
title_fullStr	Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy
title_full_unstemmed	Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy
title_sort	regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/562016b5c2f0404fb94ce2ecee01b60d
work_keys_str_mv	AT yasuonakai regionalabnormalityoffunctionalconnectivityisassociatedwithclinicalmanifestationsinindividualswithintractablefocalepilepsy AT hirokinishibayashi regionalabnormalityoffunctionalconnectivityisassociatedwithclinicalmanifestationsinindividualswithintractablefocalepilepsy AT tomohirodonishi regionalabnormalityoffunctionalconnectivityisassociatedwithclinicalmanifestationsinindividualswithintractablefocalepilepsy AT masakiterada regionalabnormalityoffunctionalconnectivityisassociatedwithclinicalmanifestationsinindividualswithintractablefocalepilepsy AT naoyukinakao regionalabnormalityoffunctionalconnectivityisassociatedwithclinicalmanifestationsinindividualswithintractablefocalepilepsy AT yoshikikaneoke regionalabnormalityoffunctionalconnectivityisassociatedwithclinicalmanifestationsinindividualswithintractablefocalepilepsy
_version_	1718392141007290368

Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy

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