Efficacy of twice-daily vs once-daily sessions of repetitive transcranial magnetic stimulation in the treatment of major depressive disorder: a retrospective study

Mandana Modirrousta,1,2 Benjamin P Meek,2 Sara L Wikstrom2 1Department of Psychiatry, University of Manitoba, 2Mental Health, Saint Boniface General Hospital, Winnipeg, MB, Canada Purpose: There is no clinical consensus on the optimal protocol for the treatment of major depressive disorder (MDD) u...

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Autores principales:	Modirrousta M, Meek BP, Wikstrom SL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Brain Stimulation Affective Disorders Treatment Protocol Treatment Effectiveness Accelerated Protocol Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/56206108b0cf4984b8c1e6ae6cc4de32
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spelling	oai:doaj.org-article:56206108b0cf4984b8c1e6ae6cc4de322021-12-02T03:12:04ZEfficacy of twice-daily vs once-daily sessions of repetitive transcranial magnetic stimulation in the treatment of major depressive disorder: a retrospective study1178-2021https://doaj.org/article/56206108b0cf4984b8c1e6ae6cc4de322018-01-01T00:00:00Zhttps://www.dovepress.com/efficacy-of-twice-daily-vs-once-daily-sessions-of-repetitive-transcran-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Mandana Modirrousta,1,2 Benjamin P Meek,2 Sara L Wikstrom2 1Department of Psychiatry, University of Manitoba, 2Mental Health, Saint Boniface General Hospital, Winnipeg, MB, Canada Purpose: There is no clinical consensus on the optimal protocol for the treatment of major depressive disorder (MDD) using repetitive transcranial magnetic stimulation (rTMS). Accelerated protocols using more than a single session of treatment per day have been suggested as a means to reduce the overall length of time required for rTMS therapy. The objective of this study is to compare the treatment outcomes of patients with MDD who received two sessions of rTMS per day vs those who received one session per day, keeping the overall number of delivered pulses constant.Patients and methods: In a retrospective study, we compared treatment outcomes of 36 patients with MDD who received 30 sessions of high-frequency (10 Hz) rTMS over the left dorsolateral prefrontal cortex. Patients received 3,000 pulses per session (5 s trains, 25 s intertrain interval) at 110% of resting motor threshold using a figure-eight coil. Patients received either two rTMS sessions per day (n=17) or one session per day (n=19). Depression symptoms were assessed by a psychiatrist using the Hamilton Rating Scale for Depression at baseline and after every 10 sessions of rTMS.Results: The majority of patients in both groups responded to treatment, and there was a trend toward greater response rate in the twice-daily (TD) group (82.4%) compared to the once-daily (OD) group (52.6%). TD stimulation was tolerable for patients and produced no adverse side effects. Patients in the TD group experienced an improvement in symptoms faster than the OD group due to the accelerated therapy period.Conclusion: Administration of two rTMS treatment sessions per day is tolerable for patients and does not seem to be inferior in efficacy to a OD protocol. TD administration has the benefit of producing symptom improvement over a shorter time span and requires fewer visits to the clinic. Keywords: brain stimulation, affective disorders, treatment protocol, treatment effectiveness, accelerated protocolModirrousta MMeek BPWikstrom SLDove Medical PressarticleBrain StimulationAffective DisordersTreatment ProtocolTreatment EffectivenessAccelerated ProtocolNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 309-316 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Brain Stimulation Affective Disorders Treatment Protocol Treatment Effectiveness Accelerated Protocol Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Brain Stimulation Affective Disorders Treatment Protocol Treatment Effectiveness Accelerated Protocol Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Modirrousta M Meek BP Wikstrom SL Efficacy of twice-daily vs once-daily sessions of repetitive transcranial magnetic stimulation in the treatment of major depressive disorder: a retrospective study
description	Mandana Modirrousta,1,2 Benjamin P Meek,2 Sara L Wikstrom2 1Department of Psychiatry, University of Manitoba, 2Mental Health, Saint Boniface General Hospital, Winnipeg, MB, Canada Purpose: There is no clinical consensus on the optimal protocol for the treatment of major depressive disorder (MDD) using repetitive transcranial magnetic stimulation (rTMS). Accelerated protocols using more than a single session of treatment per day have been suggested as a means to reduce the overall length of time required for rTMS therapy. The objective of this study is to compare the treatment outcomes of patients with MDD who received two sessions of rTMS per day vs those who received one session per day, keeping the overall number of delivered pulses constant.Patients and methods: In a retrospective study, we compared treatment outcomes of 36 patients with MDD who received 30 sessions of high-frequency (10 Hz) rTMS over the left dorsolateral prefrontal cortex. Patients received 3,000 pulses per session (5 s trains, 25 s intertrain interval) at 110% of resting motor threshold using a figure-eight coil. Patients received either two rTMS sessions per day (n=17) or one session per day (n=19). Depression symptoms were assessed by a psychiatrist using the Hamilton Rating Scale for Depression at baseline and after every 10 sessions of rTMS.Results: The majority of patients in both groups responded to treatment, and there was a trend toward greater response rate in the twice-daily (TD) group (82.4%) compared to the once-daily (OD) group (52.6%). TD stimulation was tolerable for patients and produced no adverse side effects. Patients in the TD group experienced an improvement in symptoms faster than the OD group due to the accelerated therapy period.Conclusion: Administration of two rTMS treatment sessions per day is tolerable for patients and does not seem to be inferior in efficacy to a OD protocol. TD administration has the benefit of producing symptom improvement over a shorter time span and requires fewer visits to the clinic. Keywords: brain stimulation, affective disorders, treatment protocol, treatment effectiveness, accelerated protocol
format	article
author	Modirrousta M Meek BP Wikstrom SL
author_facet	Modirrousta M Meek BP Wikstrom SL
author_sort	Modirrousta M
title	Efficacy of twice-daily vs once-daily sessions of repetitive transcranial magnetic stimulation in the treatment of major depressive disorder: a retrospective study
title_short	Efficacy of twice-daily vs once-daily sessions of repetitive transcranial magnetic stimulation in the treatment of major depressive disorder: a retrospective study
title_full	Efficacy of twice-daily vs once-daily sessions of repetitive transcranial magnetic stimulation in the treatment of major depressive disorder: a retrospective study
title_fullStr	Efficacy of twice-daily vs once-daily sessions of repetitive transcranial magnetic stimulation in the treatment of major depressive disorder: a retrospective study
title_full_unstemmed	Efficacy of twice-daily vs once-daily sessions of repetitive transcranial magnetic stimulation in the treatment of major depressive disorder: a retrospective study
title_sort	efficacy of twice-daily vs once-daily sessions of repetitive transcranial magnetic stimulation in the treatment of major depressive disorder: a retrospective study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/56206108b0cf4984b8c1e6ae6cc4de32
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Efficacy of twice-daily vs once-daily sessions of repetitive transcranial magnetic stimulation in the treatment of major depressive disorder: a retrospective study

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