Survival analysis in lung cancer patients with interstitial lung disease.

<h4>Objective</h4>Lung cancer patients with interstitial lung disease (ILD) are prone for higher morbidity and mortality and their treatment is challenging. The purpose of this study is to investigate whether the survival of lung cancer patients is affected by the presence of ILD documen...

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Autores principales:	Hassan Alomaish, Yee Ung, Stella Wang, Pascal N Tyrrell, Saly Abo Zahra, Anastasia Oikonomou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/562154fad5ef47b18a2f7ed0a2946e76
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spelling	oai:doaj.org-article:562154fad5ef47b18a2f7ed0a2946e762021-12-02T20:04:43ZSurvival analysis in lung cancer patients with interstitial lung disease.1932-620310.1371/journal.pone.0255375https://doaj.org/article/562154fad5ef47b18a2f7ed0a2946e762021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255375https://doaj.org/toc/1932-6203<h4>Objective</h4>Lung cancer patients with interstitial lung disease (ILD) are prone for higher morbidity and mortality and their treatment is challenging. The purpose of this study is to investigate whether the survival of lung cancer patients is affected by the presence of ILD documented on CT.<h4>Materials and methods</h4>146 patients with ILD at initial chest CT were retrospectively included in the study. 146 lung cancer controls without ILD were selected. Chest CTs were evaluated for the presence of pulmonary fibrosis which was classified in 4 categories. Presence and type of emphysema, extent of ILD and emphysema, location and histologic type of cancer, clinical staging and treatment were evaluated. Kaplan-Meier estimates and Cox regression models were used to assess survival probability and hazard of death of different groups. P value < 0.05 was considered significant.<h4>Results</h4>5-year survival for the study group was 41% versus 48% for the control group (log-rank test p = 0.0092). No significant difference in survival rate was found between the four different categories of ILD (log-rank test, p = 0.195) and the different histologic types (log-rank test, p = 0.4005). A cox proportional hazard model was used including presence of ILD, clinical stage and age. The hazard of death among patients with ILD was 1.522 times that among patients without ILD (95%CI, p = 0.029).<h4>Conclusion</h4>Patients with lung cancer and CT evidence of ILD have a significantly shorter survival compared to patients with lung cancer only. Documenting the type and grading the severity of ILD in lung cancer patients will significantly contribute to their challenging management.Hassan AlomaishYee UngStella WangPascal N TyrrellSaly Abo ZahraAnastasia OikonomouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0255375 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hassan Alomaish Yee Ung Stella Wang Pascal N Tyrrell Saly Abo Zahra Anastasia Oikonomou Survival analysis in lung cancer patients with interstitial lung disease.
description	<h4>Objective</h4>Lung cancer patients with interstitial lung disease (ILD) are prone for higher morbidity and mortality and their treatment is challenging. The purpose of this study is to investigate whether the survival of lung cancer patients is affected by the presence of ILD documented on CT.<h4>Materials and methods</h4>146 patients with ILD at initial chest CT were retrospectively included in the study. 146 lung cancer controls without ILD were selected. Chest CTs were evaluated for the presence of pulmonary fibrosis which was classified in 4 categories. Presence and type of emphysema, extent of ILD and emphysema, location and histologic type of cancer, clinical staging and treatment were evaluated. Kaplan-Meier estimates and Cox regression models were used to assess survival probability and hazard of death of different groups. P value < 0.05 was considered significant.<h4>Results</h4>5-year survival for the study group was 41% versus 48% for the control group (log-rank test p = 0.0092). No significant difference in survival rate was found between the four different categories of ILD (log-rank test, p = 0.195) and the different histologic types (log-rank test, p = 0.4005). A cox proportional hazard model was used including presence of ILD, clinical stage and age. The hazard of death among patients with ILD was 1.522 times that among patients without ILD (95%CI, p = 0.029).<h4>Conclusion</h4>Patients with lung cancer and CT evidence of ILD have a significantly shorter survival compared to patients with lung cancer only. Documenting the type and grading the severity of ILD in lung cancer patients will significantly contribute to their challenging management.
format	article
author	Hassan Alomaish Yee Ung Stella Wang Pascal N Tyrrell Saly Abo Zahra Anastasia Oikonomou
author_facet	Hassan Alomaish Yee Ung Stella Wang Pascal N Tyrrell Saly Abo Zahra Anastasia Oikonomou
author_sort	Hassan Alomaish
title	Survival analysis in lung cancer patients with interstitial lung disease.
title_short	Survival analysis in lung cancer patients with interstitial lung disease.
title_full	Survival analysis in lung cancer patients with interstitial lung disease.
title_fullStr	Survival analysis in lung cancer patients with interstitial lung disease.
title_full_unstemmed	Survival analysis in lung cancer patients with interstitial lung disease.
title_sort	survival analysis in lung cancer patients with interstitial lung disease.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/562154fad5ef47b18a2f7ed0a2946e76
work_keys_str_mv	AT hassanalomaish survivalanalysisinlungcancerpatientswithinterstitiallungdisease AT yeeung survivalanalysisinlungcancerpatientswithinterstitiallungdisease AT stellawang survivalanalysisinlungcancerpatientswithinterstitiallungdisease AT pascalntyrrell survivalanalysisinlungcancerpatientswithinterstitiallungdisease AT salyabozahra survivalanalysisinlungcancerpatientswithinterstitiallungdisease AT anastasiaoikonomou survivalanalysisinlungcancerpatientswithinterstitiallungdisease
_version_	1718375541921284096

Survival analysis in lung cancer patients with interstitial lung disease.

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