Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer

Prostate cancer (PCa) is a carcinoma in which fatty acids are abundant. Fatty acid metabolism is rewired during PCa development. Although PCa can be treated with hormone therapy, after prolonged treatment, castration-resistant prostate cancer can develop and can lead to increased mortality. Changes...

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Autores principales:	Huan Xu, Yanbo Chen, Meng Gu, Chong Liu, Qi Chen, Ming Zhan, Zhong Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neuroendocrine prostate cancer castration-resistant prostate cancer fatty acid metabolic reprogramming Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/5626b08875b14514960eca5f3aad3acf
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id	oai:doaj.org-article:5626b08875b14514960eca5f3aad3acf
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spelling	oai:doaj.org-article:5626b08875b14514960eca5f3aad3acf2021-11-25T18:20:45ZFatty Acid Metabolism Reprogramming in Advanced Prostate Cancer10.3390/metabo111107652218-1989https://doaj.org/article/5626b08875b14514960eca5f3aad3acf2021-11-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/765https://doaj.org/toc/2218-1989Prostate cancer (PCa) is a carcinoma in which fatty acids are abundant. Fatty acid metabolism is rewired during PCa development. Although PCa can be treated with hormone therapy, after prolonged treatment, castration-resistant prostate cancer can develop and can lead to increased mortality. Changes to fatty acid metabolism occur systemically and locally in prostate cancer patients, and understanding these changes may lead to individualized treatments, especially in advanced, castration-resistant prostate cancers. The fatty acid metabolic changes are not merely reflective of oncogenic activity, but in many cases, these represent a critical factor in cancer initiation and development. In this review, we analyzed the literature regarding systemic changes to fatty acid metabolism in PCa patients and how these changes relate to obesity, diet, circulating metabolites, and peri-prostatic adipose tissue. We also analyzed cellular fatty acid metabolism in prostate cancer, including fatty acid uptake, de novo lipogenesis, fatty acid elongation, and oxidation. This review broadens our view of fatty acid switches in PCa and presents potential candidates for PCa treatment and diagnosis.Huan XuYanbo ChenMeng GuChong LiuQi ChenMing ZhanZhong WangMDPI AGarticleneuroendocrine prostate cancercastration-resistant prostate cancerfatty acidmetabolic reprogrammingMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 765, p 765 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuroendocrine prostate cancer castration-resistant prostate cancer fatty acid metabolic reprogramming Microbiology QR1-502
spellingShingle	neuroendocrine prostate cancer castration-resistant prostate cancer fatty acid metabolic reprogramming Microbiology QR1-502 Huan Xu Yanbo Chen Meng Gu Chong Liu Qi Chen Ming Zhan Zhong Wang Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer
description	Prostate cancer (PCa) is a carcinoma in which fatty acids are abundant. Fatty acid metabolism is rewired during PCa development. Although PCa can be treated with hormone therapy, after prolonged treatment, castration-resistant prostate cancer can develop and can lead to increased mortality. Changes to fatty acid metabolism occur systemically and locally in prostate cancer patients, and understanding these changes may lead to individualized treatments, especially in advanced, castration-resistant prostate cancers. The fatty acid metabolic changes are not merely reflective of oncogenic activity, but in many cases, these represent a critical factor in cancer initiation and development. In this review, we analyzed the literature regarding systemic changes to fatty acid metabolism in PCa patients and how these changes relate to obesity, diet, circulating metabolites, and peri-prostatic adipose tissue. We also analyzed cellular fatty acid metabolism in prostate cancer, including fatty acid uptake, de novo lipogenesis, fatty acid elongation, and oxidation. This review broadens our view of fatty acid switches in PCa and presents potential candidates for PCa treatment and diagnosis.
format	article
author	Huan Xu Yanbo Chen Meng Gu Chong Liu Qi Chen Ming Zhan Zhong Wang
author_facet	Huan Xu Yanbo Chen Meng Gu Chong Liu Qi Chen Ming Zhan Zhong Wang
author_sort	Huan Xu
title	Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer
title_short	Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer
title_full	Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer
title_fullStr	Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer
title_full_unstemmed	Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer
title_sort	fatty acid metabolism reprogramming in advanced prostate cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5626b08875b14514960eca5f3aad3acf
work_keys_str_mv	AT huanxu fattyacidmetabolismreprogramminginadvancedprostatecancer AT yanbochen fattyacidmetabolismreprogramminginadvancedprostatecancer AT menggu fattyacidmetabolismreprogramminginadvancedprostatecancer AT chongliu fattyacidmetabolismreprogramminginadvancedprostatecancer AT qichen fattyacidmetabolismreprogramminginadvancedprostatecancer AT mingzhan fattyacidmetabolismreprogramminginadvancedprostatecancer AT zhongwang fattyacidmetabolismreprogramminginadvancedprostatecancer
_version_	1718411320071553024

Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer

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