The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor, and reveal a function for praziquantel as a regu...

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Autores principales:	John D. Chan, Pauline M. Cupit, Gihan S. Gunaratne, John D. McCorvy, Yang Yang, Kristen Stoltz, Thomas R. Webb, Peter I. Dosa, Bryan L. Roth, Ruben Abagyan, Charles Cunningham, Jonathan S. Marchant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/562739954b0b4cf0ad3e903c389b980c
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spelling	oai:doaj.org-article:562739954b0b4cf0ad3e903c389b980c2021-12-02T14:40:59ZThe anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand10.1038/s41467-017-02084-02041-1723https://doaj.org/article/562739954b0b4cf0ad3e903c389b980c2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02084-0https://doaj.org/toc/2041-1723Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor, and reveal a function for praziquantel as a regulator of vascular tone in treated hosts.John D. ChanPauline M. CupitGihan S. GunaratneJohn D. McCorvyYang YangKristen StoltzThomas R. WebbPeter I. DosaBryan L. RothRuben AbagyanCharles CunninghamJonathan S. MarchantNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John D. Chan Pauline M. Cupit Gihan S. Gunaratne John D. McCorvy Yang Yang Kristen Stoltz Thomas R. Webb Peter I. Dosa Bryan L. Roth Ruben Abagyan Charles Cunningham Jonathan S. Marchant The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
description	Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor, and reveal a function for praziquantel as a regulator of vascular tone in treated hosts.
format	article
author	John D. Chan Pauline M. Cupit Gihan S. Gunaratne John D. McCorvy Yang Yang Kristen Stoltz Thomas R. Webb Peter I. Dosa Bryan L. Roth Ruben Abagyan Charles Cunningham Jonathan S. Marchant
author_facet	John D. Chan Pauline M. Cupit Gihan S. Gunaratne John D. McCorvy Yang Yang Kristen Stoltz Thomas R. Webb Peter I. Dosa Bryan L. Roth Ruben Abagyan Charles Cunningham Jonathan S. Marchant
author_sort	John D. Chan
title	The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
title_short	The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
title_full	The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
title_fullStr	The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
title_full_unstemmed	The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
title_sort	anthelmintic praziquantel is a human serotoninergic g-protein-coupled receptor ligand
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/562739954b0b4cf0ad3e903c389b980c
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The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

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