Beneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores

Abstract Iron deficiency (ID) commonly occurs in chronic heart failure (HF) and is associated with poor prognosis. Neither its causes nor pathophysiological significance are clearly understood. We aimed to assess iron status and the effect of iron supplementation in the rat model of post-myocardial...

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Autores principales:	Aleksandra Paterek, Marta Kępska, Barbara Sochanowicz, Ewelina Chajduk, Joanna Kołodziejczyk, Halina Polkowska-Motrenko, Marcin Kruszewski, Przemysław Leszek, Urszula Mackiewicz, Michał Mączewski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Systemic Iron Status Ferric Carboxymaltose Intravenous Iron Supplementation Sarcoplasmic Reticulum (SR) Ca2+-ATPase (SERCA) Myocardial Iron Content Medicine R Science Q
Acceso en línea:	https://doaj.org/article/562a5dcceb2d4e7bad3a8d5748dbc3f8
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spelling	oai:doaj.org-article:562a5dcceb2d4e7bad3a8d5748dbc3f82021-12-02T15:08:39ZBeneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores10.1038/s41598-018-33277-22045-2322https://doaj.org/article/562a5dcceb2d4e7bad3a8d5748dbc3f82018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33277-2https://doaj.org/toc/2045-2322Abstract Iron deficiency (ID) commonly occurs in chronic heart failure (HF) and is associated with poor prognosis. Neither its causes nor pathophysiological significance are clearly understood. We aimed to assess iron status and the effect of iron supplementation in the rat model of post-myocardial infarction (MI) HF. Four weeks after induction of MI to induce HF or sham surgery, rats received intravenous iron (ferric carboxymaltose) or saline, 4 doses in 1-week intervals. HF alone did not cause anemia, systemic or myocardial ID, but reduced myocardial ferritin, suggesting depleted cardiomyocyte iron stores. Iron therapy increased serum Fe, ferritin and transferrin saturation as well as cardiac and hepatic iron content in HF rats, but did not increase myocardial ferritin. This was accompanied by: (1) better preservation of left ventricular (LV) ejection fraction and smaller LV dilation, (2) preservation of function of Ca2+ handling proteins in LV cardiomyocytes and (3) reduced level of inflammatory marker, CRP. Furthermore, iron supplementation did not potentiate oxidative stress or have toxic effects on cardiomyocyte function, but increased activity of antioxidant defenses (cardiac superoxide dismutase). Despite lack of systemic or myocardial ID we found evidence of depleted cardiomyocyte iron stores in the rat model of HF. Furthermore we observed positive effect of iron supplementation and confirmed safety of iron supplementation in this setting.Aleksandra PaterekMarta KępskaBarbara SochanowiczEwelina ChajdukJoanna KołodziejczykHalina Polkowska-MotrenkoMarcin KruszewskiPrzemysław LeszekUrszula MackiewiczMichał MączewskiNature PortfolioarticleSystemic Iron StatusFerric CarboxymaltoseIntravenous Iron SupplementationSarcoplasmic Reticulum (SR) Ca2+-ATPase (SERCA)Myocardial Iron ContentMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Systemic Iron Status Ferric Carboxymaltose Intravenous Iron Supplementation Sarcoplasmic Reticulum (SR) Ca2+-ATPase (SERCA) Myocardial Iron Content Medicine R Science Q
spellingShingle	Systemic Iron Status Ferric Carboxymaltose Intravenous Iron Supplementation Sarcoplasmic Reticulum (SR) Ca2+-ATPase (SERCA) Myocardial Iron Content Medicine R Science Q Aleksandra Paterek Marta Kępska Barbara Sochanowicz Ewelina Chajduk Joanna Kołodziejczyk Halina Polkowska-Motrenko Marcin Kruszewski Przemysław Leszek Urszula Mackiewicz Michał Mączewski Beneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores
description	Abstract Iron deficiency (ID) commonly occurs in chronic heart failure (HF) and is associated with poor prognosis. Neither its causes nor pathophysiological significance are clearly understood. We aimed to assess iron status and the effect of iron supplementation in the rat model of post-myocardial infarction (MI) HF. Four weeks after induction of MI to induce HF or sham surgery, rats received intravenous iron (ferric carboxymaltose) or saline, 4 doses in 1-week intervals. HF alone did not cause anemia, systemic or myocardial ID, but reduced myocardial ferritin, suggesting depleted cardiomyocyte iron stores. Iron therapy increased serum Fe, ferritin and transferrin saturation as well as cardiac and hepatic iron content in HF rats, but did not increase myocardial ferritin. This was accompanied by: (1) better preservation of left ventricular (LV) ejection fraction and smaller LV dilation, (2) preservation of function of Ca2+ handling proteins in LV cardiomyocytes and (3) reduced level of inflammatory marker, CRP. Furthermore, iron supplementation did not potentiate oxidative stress or have toxic effects on cardiomyocyte function, but increased activity of antioxidant defenses (cardiac superoxide dismutase). Despite lack of systemic or myocardial ID we found evidence of depleted cardiomyocyte iron stores in the rat model of HF. Furthermore we observed positive effect of iron supplementation and confirmed safety of iron supplementation in this setting.
format	article
author	Aleksandra Paterek Marta Kępska Barbara Sochanowicz Ewelina Chajduk Joanna Kołodziejczyk Halina Polkowska-Motrenko Marcin Kruszewski Przemysław Leszek Urszula Mackiewicz Michał Mączewski
author_facet	Aleksandra Paterek Marta Kępska Barbara Sochanowicz Ewelina Chajduk Joanna Kołodziejczyk Halina Polkowska-Motrenko Marcin Kruszewski Przemysław Leszek Urszula Mackiewicz Michał Mączewski
author_sort	Aleksandra Paterek
title	Beneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores
title_short	Beneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores
title_full	Beneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores
title_fullStr	Beneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores
title_full_unstemmed	Beneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores
title_sort	beneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/562a5dcceb2d4e7bad3a8d5748dbc3f8
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Beneficial effects of intravenous iron therapy in a rat model of heart failure with preserved systemic iron status but depleted intracellular cardiac stores

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