Patient’s awareness on COPD is the strongest predictor of persistence and adherence in treatment-naïve patients in real life: a prospective cohort study

Abstract Background There is little evidence about the factors that predict persistence/adherence in treatment-naïve patients with COPD in clinical practice. The aim of this study was to evaluate persistence and adherence levels among treatment-naïve patients diagnosed with COPD who had a prescribed...

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Autores principales:	López-Pintor Elsa, Grau Justo, Lumbreras Blanca
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chronic obstructive pulmonary disease Adherence Persistence Inhaler medication Treatment-naïve patients Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/562b24f7add84333b8fc0157377f24db
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spelling	oai:doaj.org-article:562b24f7add84333b8fc0157377f24db2021-11-28T12:36:24ZPatient’s awareness on COPD is the strongest predictor of persistence and adherence in treatment-naïve patients in real life: a prospective cohort study10.1186/s12890-021-01754-61471-2466https://doaj.org/article/562b24f7add84333b8fc0157377f24db2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12890-021-01754-6https://doaj.org/toc/1471-2466Abstract Background There is little evidence about the factors that predict persistence/adherence in treatment-naïve patients with COPD in clinical practice. The aim of this study was to evaluate persistence and adherence levels among treatment-naïve patients diagnosed with COPD who had a prescribed inhaled medication, using data from real-world clinical practice. Methods Multicentric study with a 6 month-followed-up period. Patients were considered persistent if they collected all their inhaler refills. In a random sample of patients, we evaluated adherence using the Test of Adherence to Inhalers (TAI). We assessed Health Related Quality of Life (HRQL) with St George's Respiratory Questionnaire (SGRQ). Results Of the 114 patients included, 46 (40.4%) were defined as persistent. Patients who had awareness about COPD (adjusted RR 2.672, 95% CI 1.125–6.349) were more likely to be persistent; patients with multidose DPI were less likely to be persistent that those with single dose DPI (adjusted RR 0.341, 95% CI 0.133–0.877). Higher levels of SGRQ total were associated with a lower probability of persistence (adjusted RR 0.945, 95%CI 0.894–0.998). Patients who had had an appointment with their GP in the previous six months were more likely to be persistent (adjusted RR 3.107, 95% CI 1.022–9.466). Patients who had awareness about COPD and those with lower symptom SGQR score were more likely to be adherent (24/25, 96.0% vs 16/22, 72.7%, p = 0.025, and mean 29.1, sd 19.4 vs mean 41.4, sd 15.9, respectively, p = 0.026, respectively). Conclusions Less than 50% of patients were defined as persistent. Patients’ awareness of their disease and levels of HRQL were associated with high rate of persistence and adherence. In addition, frequent visits to general practitioner, increases the rate of persistence to treatment.López-Pintor ElsaGrau JustoLumbreras BlancaBMCarticleChronic obstructive pulmonary diseaseAdherencePersistenceInhaler medicationTreatment-naïve patientsDiseases of the respiratory systemRC705-779ENBMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic obstructive pulmonary disease Adherence Persistence Inhaler medication Treatment-naïve patients Diseases of the respiratory system RC705-779
spellingShingle	Chronic obstructive pulmonary disease Adherence Persistence Inhaler medication Treatment-naïve patients Diseases of the respiratory system RC705-779 López-Pintor Elsa Grau Justo Lumbreras Blanca Patient’s awareness on COPD is the strongest predictor of persistence and adherence in treatment-naïve patients in real life: a prospective cohort study
description	Abstract Background There is little evidence about the factors that predict persistence/adherence in treatment-naïve patients with COPD in clinical practice. The aim of this study was to evaluate persistence and adherence levels among treatment-naïve patients diagnosed with COPD who had a prescribed inhaled medication, using data from real-world clinical practice. Methods Multicentric study with a 6 month-followed-up period. Patients were considered persistent if they collected all their inhaler refills. In a random sample of patients, we evaluated adherence using the Test of Adherence to Inhalers (TAI). We assessed Health Related Quality of Life (HRQL) with St George's Respiratory Questionnaire (SGRQ). Results Of the 114 patients included, 46 (40.4%) were defined as persistent. Patients who had awareness about COPD (adjusted RR 2.672, 95% CI 1.125–6.349) were more likely to be persistent; patients with multidose DPI were less likely to be persistent that those with single dose DPI (adjusted RR 0.341, 95% CI 0.133–0.877). Higher levels of SGRQ total were associated with a lower probability of persistence (adjusted RR 0.945, 95%CI 0.894–0.998). Patients who had had an appointment with their GP in the previous six months were more likely to be persistent (adjusted RR 3.107, 95% CI 1.022–9.466). Patients who had awareness about COPD and those with lower symptom SGQR score were more likely to be adherent (24/25, 96.0% vs 16/22, 72.7%, p = 0.025, and mean 29.1, sd 19.4 vs mean 41.4, sd 15.9, respectively, p = 0.026, respectively). Conclusions Less than 50% of patients were defined as persistent. Patients’ awareness of their disease and levels of HRQL were associated with high rate of persistence and adherence. In addition, frequent visits to general practitioner, increases the rate of persistence to treatment.
format	article
author	López-Pintor Elsa Grau Justo Lumbreras Blanca
author_facet	López-Pintor Elsa Grau Justo Lumbreras Blanca
author_sort	López-Pintor Elsa
title	Patient’s awareness on COPD is the strongest predictor of persistence and adherence in treatment-naïve patients in real life: a prospective cohort study
title_short	Patient’s awareness on COPD is the strongest predictor of persistence and adherence in treatment-naïve patients in real life: a prospective cohort study
title_full	Patient’s awareness on COPD is the strongest predictor of persistence and adherence in treatment-naïve patients in real life: a prospective cohort study
title_fullStr	Patient’s awareness on COPD is the strongest predictor of persistence and adherence in treatment-naïve patients in real life: a prospective cohort study
title_full_unstemmed	Patient’s awareness on COPD is the strongest predictor of persistence and adherence in treatment-naïve patients in real life: a prospective cohort study
title_sort	patient’s awareness on copd is the strongest predictor of persistence and adherence in treatment-naïve patients in real life: a prospective cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/562b24f7add84333b8fc0157377f24db
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Patient’s awareness on COPD is the strongest predictor of persistence and adherence in treatment-naïve patients in real life: a prospective cohort study

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