Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa

Selection on alleles contributing to human evolution is not well understood. Here, the authors investigate positive selection on skin barrier adaptation, identifying a selective sweep on involucrin alleles associated with migration out of Africa, and confirming enhancer regulatory effects with funct...

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Autores principales:	Mary Elizabeth Mathyer, Erin A. Brettmann, Alina D. Schmidt, Zane A. Goodwin, Inez Y. Oh, Ashley M. Quiggle, Eric Tycksen, Natasha Ramakrishnan, Scot J. Matkovich, Emma Guttman-Yassky, John R. Edwards, Cristina de Guzman Strong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/562d1faba6444cc8a292faa17015f06a
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spelling	oai:doaj.org-article:562d1faba6444cc8a292faa17015f06a2021-12-02T14:29:13ZSelective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa10.1038/s41467-021-22821-w2041-1723https://doaj.org/article/562d1faba6444cc8a292faa17015f06a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22821-whttps://doaj.org/toc/2041-1723Selection on alleles contributing to human evolution is not well understood. Here, the authors investigate positive selection on skin barrier adaptation, identifying a selective sweep on involucrin alleles associated with migration out of Africa, and confirming enhancer regulatory effects with functional assays.Mary Elizabeth MathyerErin A. BrettmannAlina D. SchmidtZane A. GoodwinInez Y. OhAshley M. QuiggleEric TycksenNatasha RamakrishnanScot J. MatkovichEmma Guttman-YasskyJohn R. EdwardsCristina de Guzman StrongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mary Elizabeth Mathyer Erin A. Brettmann Alina D. Schmidt Zane A. Goodwin Inez Y. Oh Ashley M. Quiggle Eric Tycksen Natasha Ramakrishnan Scot J. Matkovich Emma Guttman-Yassky John R. Edwards Cristina de Guzman Strong Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
description	Selection on alleles contributing to human evolution is not well understood. Here, the authors investigate positive selection on skin barrier adaptation, identifying a selective sweep on involucrin alleles associated with migration out of Africa, and confirming enhancer regulatory effects with functional assays.
format	article
author	Mary Elizabeth Mathyer Erin A. Brettmann Alina D. Schmidt Zane A. Goodwin Inez Y. Oh Ashley M. Quiggle Eric Tycksen Natasha Ramakrishnan Scot J. Matkovich Emma Guttman-Yassky John R. Edwards Cristina de Guzman Strong
author_facet	Mary Elizabeth Mathyer Erin A. Brettmann Alina D. Schmidt Zane A. Goodwin Inez Y. Oh Ashley M. Quiggle Eric Tycksen Natasha Ramakrishnan Scot J. Matkovich Emma Guttman-Yassky John R. Edwards Cristina de Guzman Strong
author_sort	Mary Elizabeth Mathyer
title	Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
title_short	Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
title_full	Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
title_fullStr	Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
title_full_unstemmed	Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
title_sort	selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of africa
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/562d1faba6444cc8a292faa17015f06a
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Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa

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