Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa

Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa

Selection on alleles contributing to human evolution is not well understood. Here, the authors investigate positive selection on skin barrier adaptation, identifying a selective sweep on involucrin alleles associated with migration out of Africa, and confirming enhancer regulatory effects with funct...

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Main Authors: Mary Elizabeth Mathyer, Erin A. Brettmann, Alina D. Schmidt, Zane A. Goodwin, Inez Y. Oh, Ashley M. Quiggle, Eric Tycksen, Natasha Ramakrishnan, Scot J. Matkovich, Emma Guttman-Yassky, John R. Edwards, Cristina de Guzman Strong
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/562d1faba6444cc8a292faa17015f06a
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https://doaj.org/article/562d1faba6444cc8a292faa17015f06a

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