Selective sweep for an enhancer involucrin allele identifies skin barrier adaptation out of Africa
Selection on alleles contributing to human evolution is not well understood. Here, the authors investigate positive selection on skin barrier adaptation, identifying a selective sweep on involucrin alleles associated with migration out of Africa, and confirming enhancer regulatory effects with funct...
Guardado en:
Autores principales: | Mary Elizabeth Mathyer, Erin A. Brettmann, Alina D. Schmidt, Zane A. Goodwin, Inez Y. Oh, Ashley M. Quiggle, Eric Tycksen, Natasha Ramakrishnan, Scot J. Matkovich, Emma Guttman-Yassky, John R. Edwards, Cristina de Guzman Strong |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/562d1faba6444cc8a292faa17015f06a |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Genomic scans for selective sweeps through haplotype homozygosity and allelic fixation in 14 indigenous sheep breeds from Middle East and South Asia
por: Sirous Eydivandi, et al.
Publicado: (2021) -
Drugs for the Treatment of Chronic Hand Eczema: Successes and Key Challenges [Corrigendum]
por: Dubin C, et al.
Publicado: (2021) -
Accurate high throughput alignment via line sweep-based seed processing
por: Markus Schmidt, et al.
Publicado: (2019) -
Experimental Study on Sweep Characteristics of Gas Gravity Drainage in the Interlayer Oil Reservoir
por: Hongwei Yu, et al.
Publicado: (2021) -
An ancient selective sweep linked to reproductive life history evolution in sockeye salmon
por: Andrew J. Veale, et al.
Publicado: (2017)