Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides

Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides

Abstract An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good t...

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Main Authors: Ting-Bi Hua, Cheng-Xiong Liu, Wei-Min Hu, Long Wang, Qing-Qing Yang
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/562d660b71e74882812b521caff10c29
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spelling oai:doaj.org-article:562d660b71e74882812b521caff10c292021-12-02T10:49:30ZMild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides10.1038/s41598-021-81370-w2045-2322https://doaj.org/article/562d660b71e74882812b521caff10c292021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81370-whttps://doaj.org/toc/2045-2322Abstract An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.Ting-Bi HuaCheng-Xiong LiuWei-Min HuLong WangQing-Qing YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ting-Bi Hua
Cheng-Xiong Liu
Wei-Min Hu
Long Wang
Qing-Qing Yang
Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
description Abstract An efficient [4 + 1] annulation between α-bromooximes and sulfur ylides via in situ generation of nitrosoalkenes under mild basic reaction conditions has been developed, providing an expeditious and scalable approach to synthesize biologically interesting isoxazoline derivatives with good to excellent yields.
format article
author Ting-Bi Hua
Cheng-Xiong Liu
Wei-Min Hu
Long Wang
Qing-Qing Yang
author_facet Ting-Bi Hua
Cheng-Xiong Liu
Wei-Min Hu
Long Wang
Qing-Qing Yang
author_sort Ting-Bi Hua
title Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
title_short Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
title_full Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
title_fullStr Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
title_full_unstemmed Mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
title_sort mild synthesis of isoxazoline derivatives via an efficient [4 + 1] annulation reaction of transient nitrosoalkenes and sulfur ylides
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/562d660b71e74882812b521caff10c29
work_keys_str_mv AT tingbihua mildsynthesisofisoxazolinederivativesviaanefficient41annulationreactionoftransientnitrosoalkenesandsulfurylides
AT chengxiongliu mildsynthesisofisoxazolinederivativesviaanefficient41annulationreactionoftransientnitrosoalkenesandsulfurylides
AT weiminhu mildsynthesisofisoxazolinederivativesviaanefficient41annulationreactionoftransientnitrosoalkenesandsulfurylides
AT longwang mildsynthesisofisoxazolinederivativesviaanefficient41annulationreactionoftransientnitrosoalkenesandsulfurylides
AT qingqingyang mildsynthesisofisoxazolinederivativesviaanefficient41annulationreactionoftransientnitrosoalkenesandsulfurylides
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