Topical Platelet Lysate Hydrogel in Patients With Anal Fissure

Background Anal fissure is a painful tear or crack in the distal part of anal canal. It usually involves the epithelium, but in the long term it may extend to the whole anal mucosa. Platelet Lysate (PL) hydrogel is a hemoderivitive pharmaceutical formulation that contains plenty of growth factors....

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Autores principales:	Akram Jamshidzadeh, Zeinab Mardani, Leila Ghahramani, Soleiman Mohammadi, Seyed Mojtaba Seyed Raoufi, Alireza Safarpour, Ahmad Izadpanah, Seyed Vahid Hosseini, Masoumeh Rahimi
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2014
Materias:	platelet hydrogel wound healing Medicine R
Acceso en línea:	https://doaj.org/article/56310eeb763146dbb23326ac9fd007d4
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spelling	oai:doaj.org-article:56310eeb763146dbb23326ac9fd007d42021-11-14T07:57:25ZTopical Platelet Lysate Hydrogel in Patients With Anal Fissure2783-243010.17795/acr-24266https://doaj.org/article/56310eeb763146dbb23326ac9fd007d42014-09-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_45472_5c226bf492b0b73c0f6c302caa55bd28.pdfhttps://doaj.org/toc/2783-2430Background Anal fissure is a painful tear or crack in the distal part of anal canal. It usually involves the epithelium, but in the long term it may extend to the whole anal mucosa. Platelet Lysate (PL) hydrogel is a hemoderivitive pharmaceutical formulation that contains plenty of growth factors. These growth factors can induce tissue regeneration and revascularization as well as fibroblast proliferation. Objectives This study aimed to evaluate the effectiveness of PL hydrogel in the treatment of the anal fissure or retardation of its development. Patients and Methods The patients with chronic and acute anal fissure were randomly divided into groups of A and B. Group A received PL hydrogel and Rectol, while group B received placebo and Rectol. Then, they were followed and evaluated for two weeks. Results Although it was anticipated that platelet growth factors would be effective in anal fissure healing process, no significant difference was observed between the control group and the case group after the treatment. Nevertheless, a significant difference was observed within the two groups after the treatment. Conclusions PL hydrogel does not seem to have beneficial effects compared to the placebo or Rectol on the healing of anal fissure.Akram JamshidzadehZeinab MardaniLeila GhahramaniSoleiman MohammadiSeyed Mojtaba Seyed RaoufiAlireza SafarpourAhmad IzadpanahSeyed Vahid HosseiniMasoumeh RahimiShiraz University of Medical Sciencesarticleplatelethydrogelwound healingMedicineRENIranian Journal of Colorectal Research, Vol 2, Iss 3, Pp 0-0 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	platelet hydrogel wound healing Medicine R
spellingShingle	platelet hydrogel wound healing Medicine R Akram Jamshidzadeh Zeinab Mardani Leila Ghahramani Soleiman Mohammadi Seyed Mojtaba Seyed Raoufi Alireza Safarpour Ahmad Izadpanah Seyed Vahid Hosseini Masoumeh Rahimi Topical Platelet Lysate Hydrogel in Patients With Anal Fissure
description	Background Anal fissure is a painful tear or crack in the distal part of anal canal. It usually involves the epithelium, but in the long term it may extend to the whole anal mucosa. Platelet Lysate (PL) hydrogel is a hemoderivitive pharmaceutical formulation that contains plenty of growth factors. These growth factors can induce tissue regeneration and revascularization as well as fibroblast proliferation. Objectives This study aimed to evaluate the effectiveness of PL hydrogel in the treatment of the anal fissure or retardation of its development. Patients and Methods The patients with chronic and acute anal fissure were randomly divided into groups of A and B. Group A received PL hydrogel and Rectol, while group B received placebo and Rectol. Then, they were followed and evaluated for two weeks. Results Although it was anticipated that platelet growth factors would be effective in anal fissure healing process, no significant difference was observed between the control group and the case group after the treatment. Nevertheless, a significant difference was observed within the two groups after the treatment. Conclusions PL hydrogel does not seem to have beneficial effects compared to the placebo or Rectol on the healing of anal fissure.
format	article
author	Akram Jamshidzadeh Zeinab Mardani Leila Ghahramani Soleiman Mohammadi Seyed Mojtaba Seyed Raoufi Alireza Safarpour Ahmad Izadpanah Seyed Vahid Hosseini Masoumeh Rahimi
author_facet	Akram Jamshidzadeh Zeinab Mardani Leila Ghahramani Soleiman Mohammadi Seyed Mojtaba Seyed Raoufi Alireza Safarpour Ahmad Izadpanah Seyed Vahid Hosseini Masoumeh Rahimi
author_sort	Akram Jamshidzadeh
title	Topical Platelet Lysate Hydrogel in Patients With Anal Fissure
title_short	Topical Platelet Lysate Hydrogel in Patients With Anal Fissure
title_full	Topical Platelet Lysate Hydrogel in Patients With Anal Fissure
title_fullStr	Topical Platelet Lysate Hydrogel in Patients With Anal Fissure
title_full_unstemmed	Topical Platelet Lysate Hydrogel in Patients With Anal Fissure
title_sort	topical platelet lysate hydrogel in patients with anal fissure
publisher	Shiraz University of Medical Sciences
publishDate	2014
url	https://doaj.org/article/56310eeb763146dbb23326ac9fd007d4
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Topical Platelet Lysate Hydrogel in Patients With Anal Fissure

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