CHANGES IN MONOCYTE ADHESION TO ENDOTHELIAL CELLS UNDER THE INFLUENCE OF STREPTOCOCCUS PYOGENES COMPONENTS

Abstract. Adhesion to blood vessel endothelium is an important stage of leukocyte migration. This study was aimed for studying the effects of supernates from ultrasound-destroyed Streptococcus pyogenes (SUDS) upon adhesive properties and adherence degree of THP-1 myelomonocytic leukemia cells to EA....

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Autores principales:	A. M. Lebedeva, E. A. Starikova, L. A. Burova, I. S. Freidlin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	endothelial cells thp-1 adhesion streptococcus pyogenes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/56316e5a034c4739afa85cfa0b89a1ad
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spelling	oai:doaj.org-article:56316e5a034c4739afa85cfa0b89a1ad2021-11-18T08:03:43ZCHANGES IN MONOCYTE ADHESION TO ENDOTHELIAL CELLS UNDER THE INFLUENCE OF STREPTOCOCCUS PYOGENES COMPONENTS1563-06252313-741X10.15789/1563-0625-2011-6-581-588https://doaj.org/article/56316e5a034c4739afa85cfa0b89a1ad2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/605https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Adhesion to blood vessel endothelium is an important stage of leukocyte migration. This study was aimed for studying the effects of supernates from ultrasound-destroyed Streptococcus pyogenes (SUDS) upon adhesive properties and adherence degree of THP-1 myelomonocytic leukemia cells to EA.hy926 endothelial cells. After 24-hour incubation of THP-1 cells with SUDS, a reduction in CD49d expression levels on these cells is observed. Plastic adherence of endothelial cells was reduced in presence of SUDS, whereas similarly treated THP-1 cells become more adherent to plastic surfaces. A 24-hour pre-incubation of THP-1 cells with SUDS resulted in reduction of their adherence to endothelium, either with SUDS-treated, or non-treated endothelium cultures. Prolonged incubation of endothelial cells with SUDS caused an increase in adherence of intact THP-1 cells to endothelium. Hence, the adhesion properties of endothelial and THP-1 cells are changed in different ways under the influence of streptococcal components. Such variability may be due to involvement of different cellular receptors for monocytes and endothelial cells during recognition of bacterial components. (Med. Immunol., 2011, vol. 13, n 6, pp 581-588)A. M. LebedevaE. A. StarikovaL. A. BurovaI. S. FreidlinSPb RAACIarticleendothelial cellsthp-1adhesionstreptococcus pyogenesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 6, Pp 581-588 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	endothelial cells thp-1 adhesion streptococcus pyogenes Immunologic diseases. Allergy RC581-607
spellingShingle	endothelial cells thp-1 adhesion streptococcus pyogenes Immunologic diseases. Allergy RC581-607 A. M. Lebedeva E. A. Starikova L. A. Burova I. S. Freidlin CHANGES IN MONOCYTE ADHESION TO ENDOTHELIAL CELLS UNDER THE INFLUENCE OF STREPTOCOCCUS PYOGENES COMPONENTS
description	Abstract. Adhesion to blood vessel endothelium is an important stage of leukocyte migration. This study was aimed for studying the effects of supernates from ultrasound-destroyed Streptococcus pyogenes (SUDS) upon adhesive properties and adherence degree of THP-1 myelomonocytic leukemia cells to EA.hy926 endothelial cells. After 24-hour incubation of THP-1 cells with SUDS, a reduction in CD49d expression levels on these cells is observed. Plastic adherence of endothelial cells was reduced in presence of SUDS, whereas similarly treated THP-1 cells become more adherent to plastic surfaces. A 24-hour pre-incubation of THP-1 cells with SUDS resulted in reduction of their adherence to endothelium, either with SUDS-treated, or non-treated endothelium cultures. Prolonged incubation of endothelial cells with SUDS caused an increase in adherence of intact THP-1 cells to endothelium. Hence, the adhesion properties of endothelial and THP-1 cells are changed in different ways under the influence of streptococcal components. Such variability may be due to involvement of different cellular receptors for monocytes and endothelial cells during recognition of bacterial components. (Med. Immunol., 2011, vol. 13, n 6, pp 581-588)
format	article
author	A. M. Lebedeva E. A. Starikova L. A. Burova I. S. Freidlin
author_facet	A. M. Lebedeva E. A. Starikova L. A. Burova I. S. Freidlin
author_sort	A. M. Lebedeva
title	CHANGES IN MONOCYTE ADHESION TO ENDOTHELIAL CELLS UNDER THE INFLUENCE OF STREPTOCOCCUS PYOGENES COMPONENTS
title_short	CHANGES IN MONOCYTE ADHESION TO ENDOTHELIAL CELLS UNDER THE INFLUENCE OF STREPTOCOCCUS PYOGENES COMPONENTS
title_full	CHANGES IN MONOCYTE ADHESION TO ENDOTHELIAL CELLS UNDER THE INFLUENCE OF STREPTOCOCCUS PYOGENES COMPONENTS
title_fullStr	CHANGES IN MONOCYTE ADHESION TO ENDOTHELIAL CELLS UNDER THE INFLUENCE OF STREPTOCOCCUS PYOGENES COMPONENTS
title_full_unstemmed	CHANGES IN MONOCYTE ADHESION TO ENDOTHELIAL CELLS UNDER THE INFLUENCE OF STREPTOCOCCUS PYOGENES COMPONENTS
title_sort	changes in monocyte adhesion to endothelial cells under the influence of streptococcus pyogenes components
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/56316e5a034c4739afa85cfa0b89a1ad
work_keys_str_mv	AT amlebedeva changesinmonocyteadhesiontoendothelialcellsundertheinfluenceofstreptococcuspyogenescomponents AT eastarikova changesinmonocyteadhesiontoendothelialcellsundertheinfluenceofstreptococcuspyogenescomponents AT laburova changesinmonocyteadhesiontoendothelialcellsundertheinfluenceofstreptococcuspyogenescomponents AT isfreidlin changesinmonocyteadhesiontoendothelialcellsundertheinfluenceofstreptococcuspyogenescomponents
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CHANGES IN MONOCYTE ADHESION TO ENDOTHELIAL CELLS UNDER THE INFLUENCE OF STREPTOCOCCUS PYOGENES COMPONENTS

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