Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis

Physical exercise may activate a number of important biochemical processes in the human body. The aim of this systematic review and meta-analysis was to identify the long-term effect of physical activity on irisin blood levels. We searched PubMed, Scopus, and Web of Science for articles addressing t...

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Autores principales: Tereza Jandova, Angel Buendía-Romero, Hana Polanska, Veronika Hola, Marcela Rihova, Tomas Vetrovsky, Javier Courel-Ibáñez, Michal Steffl
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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R
Acceso en línea:https://doaj.org/article/56360cd836ee4f6a8b7b2d1c3383d7d7
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Sumario:Physical exercise may activate a number of important biochemical processes in the human body. The aim of this systematic review and meta-analysis was to identify the long-term effect of physical activity on irisin blood levels. We searched PubMed, Scopus, and Web of Science for articles addressing the long-term effect of physical exercise on irisin blood levels. Fifty-nine articles were included in the final qualitative and quantitative syntheses. A statistically significant within-group effect of exercise on irisin blood levels was in 33 studies; out of them, the irisin level increased 23× and decreased 10×. The significant positive between-groups effect was found 11×. Furthermore, the meta-analysis indicated that physical exercise had a significant positive effect on irisin blood levels (SMD = 0.39 (95% CI 0.27–0.52)). Nevertheless, considerably high heterogeneity was found in all the analyses. This systematic review and meta-analysis indicate that physical exercise might increase irisin blood levels; however, the results of individual studies were considerably inconsistent, which questions the methodological detection of irisin by ELISA kits.