Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis
Physical exercise may activate a number of important biochemical processes in the human body. The aim of this systematic review and meta-analysis was to identify the long-term effect of physical activity on irisin blood levels. We searched PubMed, Scopus, and Web of Science for articles addressing t...
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MDPI AG
2021
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oai:doaj.org-article:56360cd836ee4f6a8b7b2d1c3383d7d72021-11-25T17:43:55ZLong-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis10.3390/healthcare91114382227-9032https://doaj.org/article/56360cd836ee4f6a8b7b2d1c3383d7d72021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1438https://doaj.org/toc/2227-9032Physical exercise may activate a number of important biochemical processes in the human body. The aim of this systematic review and meta-analysis was to identify the long-term effect of physical activity on irisin blood levels. We searched PubMed, Scopus, and Web of Science for articles addressing the long-term effect of physical exercise on irisin blood levels. Fifty-nine articles were included in the final qualitative and quantitative syntheses. A statistically significant within-group effect of exercise on irisin blood levels was in 33 studies; out of them, the irisin level increased 23× and decreased 10×. The significant positive between-groups effect was found 11×. Furthermore, the meta-analysis indicated that physical exercise had a significant positive effect on irisin blood levels (SMD = 0.39 (95% CI 0.27–0.52)). Nevertheless, considerably high heterogeneity was found in all the analyses. This systematic review and meta-analysis indicate that physical exercise might increase irisin blood levels; however, the results of individual studies were considerably inconsistent, which questions the methodological detection of irisin by ELISA kits.Tereza JandovaAngel Buendía-RomeroHana PolanskaVeronika HolaMarcela RihovaTomas VetrovskyJavier Courel-IbáñezMichal StefflMDPI AGarticlephysical activitymyokineshealthinterventionMedicineRENHealthcare, Vol 9, Iss 1438, p 1438 (2021) |
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DOAJ |
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physical activity myokines health intervention Medicine R |
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physical activity myokines health intervention Medicine R Tereza Jandova Angel Buendía-Romero Hana Polanska Veronika Hola Marcela Rihova Tomas Vetrovsky Javier Courel-Ibáñez Michal Steffl Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis |
| description |
Physical exercise may activate a number of important biochemical processes in the human body. The aim of this systematic review and meta-analysis was to identify the long-term effect of physical activity on irisin blood levels. We searched PubMed, Scopus, and Web of Science for articles addressing the long-term effect of physical exercise on irisin blood levels. Fifty-nine articles were included in the final qualitative and quantitative syntheses. A statistically significant within-group effect of exercise on irisin blood levels was in 33 studies; out of them, the irisin level increased 23× and decreased 10×. The significant positive between-groups effect was found 11×. Furthermore, the meta-analysis indicated that physical exercise had a significant positive effect on irisin blood levels (SMD = 0.39 (95% CI 0.27–0.52)). Nevertheless, considerably high heterogeneity was found in all the analyses. This systematic review and meta-analysis indicate that physical exercise might increase irisin blood levels; however, the results of individual studies were considerably inconsistent, which questions the methodological detection of irisin by ELISA kits. |
| format |
article |
| author |
Tereza Jandova Angel Buendía-Romero Hana Polanska Veronika Hola Marcela Rihova Tomas Vetrovsky Javier Courel-Ibáñez Michal Steffl |
| author_facet |
Tereza Jandova Angel Buendía-Romero Hana Polanska Veronika Hola Marcela Rihova Tomas Vetrovsky Javier Courel-Ibáñez Michal Steffl |
| author_sort |
Tereza Jandova |
| title |
Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis |
| title_short |
Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis |
| title_full |
Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis |
| title_fullStr |
Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis |
| title_full_unstemmed |
Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis |
| title_sort |
long-term effect of exercise on irisin blood levels—systematic review and meta-analysis |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/56360cd836ee4f6a8b7b2d1c3383d7d7 |
| work_keys_str_mv |
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