Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

Chemokine receptors are GPCRs involved in immune responses and regulated by small protein ligands known as chemokines. A structural study of the human CCR6/CCL20–Go complex reveals that CCL20 binds in a shallow extracellular pocket, and suggests that activation of CCR6 by CCL20 binding involves an a...

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Autores principales: David Jonathan Wasilko, Zachary Lee Johnson, Mark Ammirati, Ye Che, Matthew C. Griffor, Seungil Han, Huixian Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/563862bc1d384d9c84f3cca32e285ede
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