Assessment of Beta-Cell Function During Pregnancy and after Delivery

The aim of the present study was to assess β-cell function using homeostasis model (HOMA-B) and disposition index (DI) in pregnant women with/without gestational diabetes, and after delivery. A total of 102 pregnant women between 24-28 gestational weeks (53 with gestational diabetes mellitus (GDM) a...

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Autores principales:	Genova M. P., Todorova-Ananieva K., Atanasova B., Tzatchev K.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2014
Materias:	gestational diabetes mellitus β-cell function homeostasis model assessment disposition index Medicine R
Acceso en línea:	https://doaj.org/article/56386de4b0a94aeeac0e5f5be8c14a15
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spelling	oai:doaj.org-article:56386de4b0a94aeeac0e5f5be8c14a152021-12-02T19:05:13ZAssessment of Beta-Cell Function During Pregnancy and after Delivery0324-175010.2478/amb-2014-0001https://doaj.org/article/56386de4b0a94aeeac0e5f5be8c14a152014-06-01T00:00:00Zhttps://doi.org/10.2478/amb-2014-0001https://doaj.org/toc/0324-1750The aim of the present study was to assess β-cell function using homeostasis model (HOMA-B) and disposition index (DI) in pregnant women with/without gestational diabetes, and after delivery. A total of 102 pregnant women between 24-28 gestational weeks (53 with gestational diabetes mellitus (GDM) and 49 with normal glucose tolerance (NGT) and 22 GDM postpartum women (8-12 weeks after delivery) were included in the study. All postpartum women had a history of GDM. HOMA indexes (insulin resistance - HOMA-IR and HOMA-B for assessing β-cell function) were calculated from fasting glucose and insulin concentrations. To estimate insulin secretion independent of insulin sensitivity, DI was calculated using glucose and insulin levels at 0 and 60 min during the course of a 2 h 75g oral glucose tolerance test (OGTT). In GDM pregnant women HOMA-B was significantly lower compared to NGT women (p = 0.017), but there was no significant difference compared to women after birth (NS). There was difference between NGT and postpartum women (p < 0.05). DI was significantly lower for GDM pregnant women in comparison to NGT and postpartum women (p < 0.0001; p = 0.011), between NGT and women after birth (p < 0.04). In our study, comparison of НОМА-В in NGT and GDM pregnant women demonstrated that the OR of developing GDM was 0.989 (95% CI, 0.980-0.998, P = 0.013), and comparison of DI in healthy pregnant and GDM showed that the OR of developing GDM was 0.967 (95% CI, 0.947-0.988, P = 0.002). Therefore, HOMA-B and DI appear to be protective factors in the risk of developing GDM. According to our results, assessment of β-cell function, using HOMA-B and DI, showed that they are lower in GDM than NGT group and postpartum women. It is important to note that HOMA-B did not show significant difference between GDM pregnant and women after delivery with a history for GDM. We assume that pregnant women with GDM have a pancreatic β-cell defect that remains after birth. These women are at increased risk for developing diabetes mellitus, the most frequent type 2 diabetes, in the future after birth.Genova M. P.Todorova-Ananieva K.Atanasova B.Tzatchev K.Sciendoarticlegestational diabetes mellitusβ-cell functionhomeostasis model assessmentdisposition indexMedicineRENActa Medica Bulgarica, Vol 41, Iss 1, Pp 5-12 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	gestational diabetes mellitus β-cell function homeostasis model assessment disposition index Medicine R
spellingShingle	gestational diabetes mellitus β-cell function homeostasis model assessment disposition index Medicine R Genova M. P. Todorova-Ananieva K. Atanasova B. Tzatchev K. Assessment of Beta-Cell Function During Pregnancy and after Delivery
description	The aim of the present study was to assess β-cell function using homeostasis model (HOMA-B) and disposition index (DI) in pregnant women with/without gestational diabetes, and after delivery. A total of 102 pregnant women between 24-28 gestational weeks (53 with gestational diabetes mellitus (GDM) and 49 with normal glucose tolerance (NGT) and 22 GDM postpartum women (8-12 weeks after delivery) were included in the study. All postpartum women had a history of GDM. HOMA indexes (insulin resistance - HOMA-IR and HOMA-B for assessing β-cell function) were calculated from fasting glucose and insulin concentrations. To estimate insulin secretion independent of insulin sensitivity, DI was calculated using glucose and insulin levels at 0 and 60 min during the course of a 2 h 75g oral glucose tolerance test (OGTT). In GDM pregnant women HOMA-B was significantly lower compared to NGT women (p = 0.017), but there was no significant difference compared to women after birth (NS). There was difference between NGT and postpartum women (p < 0.05). DI was significantly lower for GDM pregnant women in comparison to NGT and postpartum women (p < 0.0001; p = 0.011), between NGT and women after birth (p < 0.04). In our study, comparison of НОМА-В in NGT and GDM pregnant women demonstrated that the OR of developing GDM was 0.989 (95% CI, 0.980-0.998, P = 0.013), and comparison of DI in healthy pregnant and GDM showed that the OR of developing GDM was 0.967 (95% CI, 0.947-0.988, P = 0.002). Therefore, HOMA-B and DI appear to be protective factors in the risk of developing GDM. According to our results, assessment of β-cell function, using HOMA-B and DI, showed that they are lower in GDM than NGT group and postpartum women. It is important to note that HOMA-B did not show significant difference between GDM pregnant and women after delivery with a history for GDM. We assume that pregnant women with GDM have a pancreatic β-cell defect that remains after birth. These women are at increased risk for developing diabetes mellitus, the most frequent type 2 diabetes, in the future after birth.
format	article
author	Genova M. P. Todorova-Ananieva K. Atanasova B. Tzatchev K.
author_facet	Genova M. P. Todorova-Ananieva K. Atanasova B. Tzatchev K.
author_sort	Genova M. P.
title	Assessment of Beta-Cell Function During Pregnancy and after Delivery
title_short	Assessment of Beta-Cell Function During Pregnancy and after Delivery
title_full	Assessment of Beta-Cell Function During Pregnancy and after Delivery
title_fullStr	Assessment of Beta-Cell Function During Pregnancy and after Delivery
title_full_unstemmed	Assessment of Beta-Cell Function During Pregnancy and after Delivery
title_sort	assessment of beta-cell function during pregnancy and after delivery
publisher	Sciendo
publishDate	2014
url	https://doaj.org/article/56386de4b0a94aeeac0e5f5be8c14a15
work_keys_str_mv	AT genovamp assessmentofbetacellfunctionduringpregnancyandafterdelivery AT todorovaananievak assessmentofbetacellfunctionduringpregnancyandafterdelivery AT atanasovab assessmentofbetacellfunctionduringpregnancyandafterdelivery AT tzatchevk assessmentofbetacellfunctionduringpregnancyandafterdelivery
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Assessment of Beta-Cell Function During Pregnancy and after Delivery

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