Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.

<h4>Introduction</h4>Severe malaria has been attributed partly to the sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the microvasculature of vital host organs. Identification of P. falciparum cytoadherence phenotypes that are associated with severe malaria may lead...

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Autores principales: Alfredo Mayor, Abdul Hafiz, Quique Bassat, Eduard Rovira-Vallbona, Sergi Sanz, Sónia Machevo, Ruth Aguilar, Pau Cisteró, Betuel Sigaúque, Clara Menéndez, Pedro L Alonso, Chetan E Chitnis
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spelling oai:doaj.org-article:563b3db666f2423eab154aee40bf6bcc2021-11-18T06:54:52ZAssociation of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.1932-620310.1371/journal.pone.0019422https://doaj.org/article/563b3db666f2423eab154aee40bf6bcc2011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21559373/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Severe malaria has been attributed partly to the sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the microvasculature of vital host organs. Identification of P. falciparum cytoadherence phenotypes that are associated with severe malaria may lead to the development of novel strategies against life-threatening malaria.<h4>Methods and findings</h4>Forty-six P. falciparum isolates from Mozambican children under 5 years of age with severe malaria (cases) were examined and compared to 46 isolates from sex and age matched Mozambican children with uncomplicated malaria (controls). Cytoadherence properties such as platelet-mediated clumping, rosetting and adhesion to purified receptors (CD36, ICAM1 and gC1qR), were compared between these matched pairs by non-parametric tests. The most common clinical presentation associated with severe malaria was prostration. Compared to matched controls, prevalence of platelet-mediated clumping was higher in cases (P = .019), in children presenting with prostration (P = .049) and in children with severe anaemia (P = .025). Prevalence of rosetting and gC1qR adhesion were also higher in isolates from cases with severe anemia and multiple seizures, respectively (P = .045 in both cases), than in controls.<h4>Conclusions</h4>These data indicate a role for platelet-mediated clumping, rosetting and adhesion to gC1qR in the pathogenesis of severe malaria. Inhibition of these cytoadherence phenotypes may reduce the occurrence or improve the prognosis of severe malaria outcomes.Alfredo MayorAbdul HafizQuique BassatEduard Rovira-VallbonaSergi SanzSónia MachevoRuth AguilarPau CisteróBetuel SigaúqueClara MenéndezPedro L AlonsoChetan E ChitnisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e19422 (2011)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Alfredo Mayor
Abdul Hafiz
Quique Bassat
Eduard Rovira-Vallbona
Sergi Sanz
Sónia Machevo
Ruth Aguilar
Pau Cisteró
Betuel Sigaúque
Clara Menéndez
Pedro L Alonso
Chetan E Chitnis
Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.
description <h4>Introduction</h4>Severe malaria has been attributed partly to the sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the microvasculature of vital host organs. Identification of P. falciparum cytoadherence phenotypes that are associated with severe malaria may lead to the development of novel strategies against life-threatening malaria.<h4>Methods and findings</h4>Forty-six P. falciparum isolates from Mozambican children under 5 years of age with severe malaria (cases) were examined and compared to 46 isolates from sex and age matched Mozambican children with uncomplicated malaria (controls). Cytoadherence properties such as platelet-mediated clumping, rosetting and adhesion to purified receptors (CD36, ICAM1 and gC1qR), were compared between these matched pairs by non-parametric tests. The most common clinical presentation associated with severe malaria was prostration. Compared to matched controls, prevalence of platelet-mediated clumping was higher in cases (P = .019), in children presenting with prostration (P = .049) and in children with severe anaemia (P = .025). Prevalence of rosetting and gC1qR adhesion were also higher in isolates from cases with severe anemia and multiple seizures, respectively (P = .045 in both cases), than in controls.<h4>Conclusions</h4>These data indicate a role for platelet-mediated clumping, rosetting and adhesion to gC1qR in the pathogenesis of severe malaria. Inhibition of these cytoadherence phenotypes may reduce the occurrence or improve the prognosis of severe malaria outcomes.
format article
author Alfredo Mayor
Abdul Hafiz
Quique Bassat
Eduard Rovira-Vallbona
Sergi Sanz
Sónia Machevo
Ruth Aguilar
Pau Cisteró
Betuel Sigaúque
Clara Menéndez
Pedro L Alonso
Chetan E Chitnis
author_facet Alfredo Mayor
Abdul Hafiz
Quique Bassat
Eduard Rovira-Vallbona
Sergi Sanz
Sónia Machevo
Ruth Aguilar
Pau Cisteró
Betuel Sigaúque
Clara Menéndez
Pedro L Alonso
Chetan E Chitnis
author_sort Alfredo Mayor
title Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.
title_short Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.
title_full Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.
title_fullStr Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.
title_full_unstemmed Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.
title_sort association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.
publisher Public Library of Science (PLoS)
publishDate 2011
url https://doaj.org/article/563b3db666f2423eab154aee40bf6bcc
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