Infants’ dietary arsenic exposure during transition to solid food

Abstract Early-life exposure to inorganic arsenic (i-As) may cause long-lasting health effects, but as yet, little is known about exposure among weaning infants. We assessed exposure before and during weaning and investigated the association between solid food intake and infants’ urinary arsenic spe...

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Autores principales:	Antonio J. Signes-Pastor, Kathryn L. Cottingham, Manus Carey, Vicki Sayarath, Thomas Palys, Andrew A. Meharg, Carol L. Folt, Margaret R. Karagas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/563bb7d127f949bfbe2d30694098ac5f
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spelling	oai:doaj.org-article:563bb7d127f949bfbe2d30694098ac5f2021-12-02T16:08:13ZInfants’ dietary arsenic exposure during transition to solid food10.1038/s41598-018-25372-12045-2322https://doaj.org/article/563bb7d127f949bfbe2d30694098ac5f2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25372-1https://doaj.org/toc/2045-2322Abstract Early-life exposure to inorganic arsenic (i-As) may cause long-lasting health effects, but as yet, little is known about exposure among weaning infants. We assessed exposure before and during weaning and investigated the association between solid food intake and infants’ urinary arsenic species concentrations. Following the recording of a comprehensive 3 day food diary, paired urine samples (pre- and post-weaning) were collected and analyzed for arsenic speciation from 15 infants participating in the New Hampshire Birth Cohort Study. Infants had higher urinary i-As (p-value = 0.04), monomethylarsonic acid (MMA) (p-value = 0.002), dimethylarsinic acid (DMA) (p-value = 0.01), and sum of arsenic species (i-As + MMA + DMA, p-value = 0.01) during weaning than while exclusively fed on a liquid diet (i.e., breast milk, formula, or a mixture of both). Among weaning infants, increased sum of urinary arsenic species was pairwise-associated with intake of rice cereal (Spearman’s ρ = 0.90, p-value = 0.03), fruit (ρ = 0.70, p-value = 0.03), and vegetables (ρ = 0.86, p-value = 0.01). Our observed increases in urinary arsenic concentrations likely indicate increased exposure to i-As during the transition to solid foods, suggests the need to minimize exposure during this critical period of development.Antonio J. Signes-PastorKathryn L. CottinghamManus CareyVicki SayarathThomas PalysAndrew A. MehargCarol L. FoltMargaret R. KaragasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antonio J. Signes-Pastor Kathryn L. Cottingham Manus Carey Vicki Sayarath Thomas Palys Andrew A. Meharg Carol L. Folt Margaret R. Karagas Infants’ dietary arsenic exposure during transition to solid food
description	Abstract Early-life exposure to inorganic arsenic (i-As) may cause long-lasting health effects, but as yet, little is known about exposure among weaning infants. We assessed exposure before and during weaning and investigated the association between solid food intake and infants’ urinary arsenic species concentrations. Following the recording of a comprehensive 3 day food diary, paired urine samples (pre- and post-weaning) were collected and analyzed for arsenic speciation from 15 infants participating in the New Hampshire Birth Cohort Study. Infants had higher urinary i-As (p-value = 0.04), monomethylarsonic acid (MMA) (p-value = 0.002), dimethylarsinic acid (DMA) (p-value = 0.01), and sum of arsenic species (i-As + MMA + DMA, p-value = 0.01) during weaning than while exclusively fed on a liquid diet (i.e., breast milk, formula, or a mixture of both). Among weaning infants, increased sum of urinary arsenic species was pairwise-associated with intake of rice cereal (Spearman’s ρ = 0.90, p-value = 0.03), fruit (ρ = 0.70, p-value = 0.03), and vegetables (ρ = 0.86, p-value = 0.01). Our observed increases in urinary arsenic concentrations likely indicate increased exposure to i-As during the transition to solid foods, suggests the need to minimize exposure during this critical period of development.
format	article
author	Antonio J. Signes-Pastor Kathryn L. Cottingham Manus Carey Vicki Sayarath Thomas Palys Andrew A. Meharg Carol L. Folt Margaret R. Karagas
author_facet	Antonio J. Signes-Pastor Kathryn L. Cottingham Manus Carey Vicki Sayarath Thomas Palys Andrew A. Meharg Carol L. Folt Margaret R. Karagas
author_sort	Antonio J. Signes-Pastor
title	Infants’ dietary arsenic exposure during transition to solid food
title_short	Infants’ dietary arsenic exposure during transition to solid food
title_full	Infants’ dietary arsenic exposure during transition to solid food
title_fullStr	Infants’ dietary arsenic exposure during transition to solid food
title_full_unstemmed	Infants’ dietary arsenic exposure during transition to solid food
title_sort	infants’ dietary arsenic exposure during transition to solid food
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/563bb7d127f949bfbe2d30694098ac5f
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Infants’ dietary arsenic exposure during transition to solid food

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