Copper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay

The synthesis of high value heterocycles from cheap starting materials remains challenging. Here, the authors develop a new strategy to realize practical and modular synthesis of N-H indoles and analogs from toluene and nitrile derivatives using naturally abundant copper salt as catalyst.

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Autores principales:	Xiang-Huan Shan, Hong-Xing Zheng, Bo Yang, Lin Tie, Jia-Le Fu, Jian-Ping Qu, Yan-Biao Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/563d47fb14df4979816cb875748aa53b
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spelling	oai:doaj.org-article:563d47fb14df4979816cb875748aa53b2021-12-02T17:01:45ZCopper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay10.1038/s41467-019-08849-z2041-1723https://doaj.org/article/563d47fb14df4979816cb875748aa53b2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08849-zhttps://doaj.org/toc/2041-1723The synthesis of high value heterocycles from cheap starting materials remains challenging. Here, the authors develop a new strategy to realize practical and modular synthesis of N-H indoles and analogs from toluene and nitrile derivatives using naturally abundant copper salt as catalyst.Xiang-Huan ShanHong-Xing ZhengBo YangLin TieJia-Le FuJian-Ping QuYan-Biao KangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiang-Huan Shan Hong-Xing Zheng Bo Yang Lin Tie Jia-Le Fu Jian-Ping Qu Yan-Biao Kang Copper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay
description	The synthesis of high value heterocycles from cheap starting materials remains challenging. Here, the authors develop a new strategy to realize practical and modular synthesis of N-H indoles and analogs from toluene and nitrile derivatives using naturally abundant copper salt as catalyst.
format	article
author	Xiang-Huan Shan Hong-Xing Zheng Bo Yang Lin Tie Jia-Le Fu Jian-Ping Qu Yan-Biao Kang
author_facet	Xiang-Huan Shan Hong-Xing Zheng Bo Yang Lin Tie Jia-Le Fu Jian-Ping Qu Yan-Biao Kang
author_sort	Xiang-Huan Shan
title	Copper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay
title_short	Copper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay
title_full	Copper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay
title_fullStr	Copper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay
title_full_unstemmed	Copper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay
title_sort	copper-catalyzed oxidative benzylic c-h cyclization via iminyl radical from intermolecular anion-radical redox relay
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/563d47fb14df4979816cb875748aa53b
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Copper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay

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