Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer

The prognostic value of the CRP to albumin ratio (CAR) among older adults with cancer is not known. Six hundred and three older outpatients with cancer and undergoing geriatric assessment before therapeutic decisions were prospectively recruited from the PF-EC cohort study. Serum albumin levels, ser...

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Autores principales:	Fiamma Burgassi, Elena Paillaud, Johanne Poisson, Guilhem Bousquet, Frédéric Pamoukdjian
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer-cachexia longitudinal trajectories CRP to albumin ratio older adults geriatric assessment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/563e13d4e14447c0928fd73c0ab14bbf
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spelling	oai:doaj.org-article:563e13d4e14447c0928fd73c0ab14bbf2021-11-25T17:03:56ZPrognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer10.3390/cancers132257822072-6694https://doaj.org/article/563e13d4e14447c0928fd73c0ab14bbf2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5782https://doaj.org/toc/2072-6694The prognostic value of the CRP to albumin ratio (CAR) among older adults with cancer is not known. Six hundred and three older outpatients with cancer and undergoing geriatric assessment before therapeutic decisions were prospectively recruited from the PF-EC cohort study. Serum albumin levels, serum CRP levels and the CAR were prospectively recorded at baseline, and at each consultation thereafter, as follows: 1, 3, 6, 9, 12, 18, 24 and 36 months. Frailty was defined as a G8-index ≤ 14. The primary endpoint was longitudinal variation in the CAR during the study follow-up. Two clusters in the longitudinal trajectories of the CAR were identified, one favourable, with lower values and better overall survival (cluster A), and the second with higher values and less favourable overall survival (cluster B). The median CAR [95% CI] for clusters A and B were respectively: 0.17 [0.04–0.48] and 0.26 [0.04–0.79] at baseline (<i>p</i> = 0.01), and 0.18 [0.02–3.17] and 0.76 [0.03–6.87] during the study follow-up (<i>p</i> < 0.0001). Cluster B was associated with the frailest patients with metastatic disease, mainly driven by a high CRP level at baseline, and low albumin during the study follow-up. Our study results suggest that the most risk-prone patients have a cancer-cachexia trajectory.Fiamma BurgassiElena PaillaudJohanne PoissonGuilhem BousquetFrédéric PamoukdjianMDPI AGarticlecancer-cachexialongitudinal trajectoriesCRP to albumin ratioolder adultsgeriatric assessmentNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5782, p 5782 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer-cachexia longitudinal trajectories CRP to albumin ratio older adults geriatric assessment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cancer-cachexia longitudinal trajectories CRP to albumin ratio older adults geriatric assessment Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Fiamma Burgassi Elena Paillaud Johanne Poisson Guilhem Bousquet Frédéric Pamoukdjian Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer
description	The prognostic value of the CRP to albumin ratio (CAR) among older adults with cancer is not known. Six hundred and three older outpatients with cancer and undergoing geriatric assessment before therapeutic decisions were prospectively recruited from the PF-EC cohort study. Serum albumin levels, serum CRP levels and the CAR were prospectively recorded at baseline, and at each consultation thereafter, as follows: 1, 3, 6, 9, 12, 18, 24 and 36 months. Frailty was defined as a G8-index ≤ 14. The primary endpoint was longitudinal variation in the CAR during the study follow-up. Two clusters in the longitudinal trajectories of the CAR were identified, one favourable, with lower values and better overall survival (cluster A), and the second with higher values and less favourable overall survival (cluster B). The median CAR [95% CI] for clusters A and B were respectively: 0.17 [0.04–0.48] and 0.26 [0.04–0.79] at baseline (<i>p</i> = 0.01), and 0.18 [0.02–3.17] and 0.76 [0.03–6.87] during the study follow-up (<i>p</i> < 0.0001). Cluster B was associated with the frailest patients with metastatic disease, mainly driven by a high CRP level at baseline, and low albumin during the study follow-up. Our study results suggest that the most risk-prone patients have a cancer-cachexia trajectory.
format	article
author	Fiamma Burgassi Elena Paillaud Johanne Poisson Guilhem Bousquet Frédéric Pamoukdjian
author_facet	Fiamma Burgassi Elena Paillaud Johanne Poisson Guilhem Bousquet Frédéric Pamoukdjian
author_sort	Fiamma Burgassi
title	Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer
title_short	Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer
title_full	Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer
title_fullStr	Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer
title_full_unstemmed	Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer
title_sort	prognostic value of prospective longitudinal crp to albumin ratio among older outpatients with cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/563e13d4e14447c0928fd73c0ab14bbf
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Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer

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