Low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: an observational cohort study based on propensity score matching

Abstract Background Since the effectiveness of low-dose aspirin (LDA) in twin pregnancies is uncertain, we aimed to preliminarily assess whether LDA is beneficial in preventing preeclampsia in twin pregnancies. Methods This study is an observational study in two hospitals in China. Among 932 women,...

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Autores principales:	Ying Ye, Li Wen, Xiyao Liu, Lan Wang, Yamin Liu, Richard Saffery, Mark D. Kilby, Chao Tong, Hongbo Qi, Philip Baker
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Low-dose aspirin Twin pregnancy Preeclampsia Preterm birth Fetal growth restriction Postpartum hemorrhage Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/563f0ba3e0a64a36938109f17358933a
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spelling	oai:doaj.org-article:563f0ba3e0a64a36938109f17358933a2021-11-28T12:29:46ZLow-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: an observational cohort study based on propensity score matching10.1186/s12884-021-04217-21471-2393https://doaj.org/article/563f0ba3e0a64a36938109f17358933a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12884-021-04217-2https://doaj.org/toc/1471-2393Abstract Background Since the effectiveness of low-dose aspirin (LDA) in twin pregnancies is uncertain, we aimed to preliminarily assess whether LDA is beneficial in preventing preeclampsia in twin pregnancies. Methods This study is an observational study in two hospitals in China. Among 932 women, 277 in the First Affiliated Hospital of Chongqing Medical University were routinely treated with aspirin (100 mg daily) from 12 to 16 weeks to 35 weeks of gestational age, while 655 in Chongqing Health Center for Women and Children were not taking aspirin during pregnancy. We followed each subject and the individual details were recorded. Results LDA significantly reduced the risk of preeclampsia (RR 0.48; 95% CI 0.24–0.95) and preterm birth 34 weeks (RR 0.50; 95% CI 0.29–0.86) and showed possible benefits to lower the rate of SGA babies (RR 0.74; 95% CI 0.55–1.00). Moreover, the risk of postpartum hemorrhage was not increased by LDA (RR 0.89; 95% CI 0.35–2.26). Conclusions Treatment with low-dose aspirin in twin pregnancies could offer some protection against adverse pregnancy outcomes in the absence of significantly increased risk of postpartum hemorrhage. Trial registration Chinese Clinical Trial Registry (ChiCTR); ChiCTR-OOC-16008203 , Retrospectively registered date: April 1st, 2016;Ying YeLi WenXiyao LiuLan WangYamin LiuRichard SafferyMark D. KilbyChao TongHongbo QiPhilip BakerBMCarticleLow-dose aspirinTwin pregnancyPreeclampsiaPreterm birthFetal growth restrictionPostpartum hemorrhageGynecology and obstetricsRG1-991ENBMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Low-dose aspirin Twin pregnancy Preeclampsia Preterm birth Fetal growth restriction Postpartum hemorrhage Gynecology and obstetrics RG1-991
spellingShingle	Low-dose aspirin Twin pregnancy Preeclampsia Preterm birth Fetal growth restriction Postpartum hemorrhage Gynecology and obstetrics RG1-991 Ying Ye Li Wen Xiyao Liu Lan Wang Yamin Liu Richard Saffery Mark D. Kilby Chao Tong Hongbo Qi Philip Baker Low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: an observational cohort study based on propensity score matching
description	Abstract Background Since the effectiveness of low-dose aspirin (LDA) in twin pregnancies is uncertain, we aimed to preliminarily assess whether LDA is beneficial in preventing preeclampsia in twin pregnancies. Methods This study is an observational study in two hospitals in China. Among 932 women, 277 in the First Affiliated Hospital of Chongqing Medical University were routinely treated with aspirin (100 mg daily) from 12 to 16 weeks to 35 weeks of gestational age, while 655 in Chongqing Health Center for Women and Children were not taking aspirin during pregnancy. We followed each subject and the individual details were recorded. Results LDA significantly reduced the risk of preeclampsia (RR 0.48; 95% CI 0.24–0.95) and preterm birth 34 weeks (RR 0.50; 95% CI 0.29–0.86) and showed possible benefits to lower the rate of SGA babies (RR 0.74; 95% CI 0.55–1.00). Moreover, the risk of postpartum hemorrhage was not increased by LDA (RR 0.89; 95% CI 0.35–2.26). Conclusions Treatment with low-dose aspirin in twin pregnancies could offer some protection against adverse pregnancy outcomes in the absence of significantly increased risk of postpartum hemorrhage. Trial registration Chinese Clinical Trial Registry (ChiCTR); ChiCTR-OOC-16008203 , Retrospectively registered date: April 1st, 2016;
format	article
author	Ying Ye Li Wen Xiyao Liu Lan Wang Yamin Liu Richard Saffery Mark D. Kilby Chao Tong Hongbo Qi Philip Baker
author_facet	Ying Ye Li Wen Xiyao Liu Lan Wang Yamin Liu Richard Saffery Mark D. Kilby Chao Tong Hongbo Qi Philip Baker
author_sort	Ying Ye
title	Low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: an observational cohort study based on propensity score matching
title_short	Low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: an observational cohort study based on propensity score matching
title_full	Low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: an observational cohort study based on propensity score matching
title_fullStr	Low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: an observational cohort study based on propensity score matching
title_full_unstemmed	Low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: an observational cohort study based on propensity score matching
title_sort	low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: an observational cohort study based on propensity score matching
publisher	BMC
publishDate	2021
url	https://doaj.org/article/563f0ba3e0a64a36938109f17358933a
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Low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: an observational cohort study based on propensity score matching

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