MELD-accelerated molecular dynamics help determine amyloid fibril structures
Sharma & Dill apply MELD x MD to provide atomistic computational models of a set of amyloid-forming protein fibrils using limited experimental information. Since MELD x MD yields not just single structure but conformational ensembles, their method can also generate polymorphs with similar backbo...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/5641364333064cdf88927f5eed39e407 |
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| Sumario: | Sharma & Dill apply MELD x MD to provide atomistic computational models of a set of amyloid-forming protein fibrils using limited experimental information. Since MELD x MD yields not just single structure but conformational ensembles, their method can also generate polymorphs with similar backbone conformations but distinct side chain packing. |
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