Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their circulating counterpart, but share a common origin...

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Autores principales:	Maria Xydia, Raheleh Rahbari, Eliana Ruggiero, Iain Macaulay, Maxime Tarabichi, Robert Lohmayer, Stefan Wilkening, Tillmann Michels, Daniel Brown, Sebastiaan Vanuytven, Svetlana Mastitskaya, Sean Laidlaw, Niels Grabe, Maria Pritsch, Raffaele Fronza, Klaus Hexel, Steffen Schmitt, Michael Müller-Steinhardt, Niels Halama, Christoph Domschke, Manfred Schmidt, Christof von Kalle, Florian Schütz, Thierry Voet, Philipp Beckhove
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/564548dac492461fa165fbbe611c1237
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spelling	oai:doaj.org-article:564548dac492461fa165fbbe611c12372021-12-02T14:21:27ZCommon clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients10.1038/s41467-021-21297-y2041-1723https://doaj.org/article/564548dac492461fa165fbbe611c12372021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21297-yhttps://doaj.org/toc/2041-1723The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their circulating counterpart, but share a common origin with intratumoral antigen-experienced conventional T cells.Maria XydiaRaheleh RahbariEliana RuggieroIain MacaulayMaxime TarabichiRobert LohmayerStefan WilkeningTillmann MichelsDaniel BrownSebastiaan VanuytvenSvetlana MastitskayaSean LaidlawNiels GrabeMaria PritschRaffaele FronzaKlaus HexelSteffen SchmittMichael Müller-SteinhardtNiels HalamaChristoph DomschkeManfred SchmidtChristof von KalleFlorian SchützThierry VoetPhilipp BeckhoveNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Xydia Raheleh Rahbari Eliana Ruggiero Iain Macaulay Maxime Tarabichi Robert Lohmayer Stefan Wilkening Tillmann Michels Daniel Brown Sebastiaan Vanuytven Svetlana Mastitskaya Sean Laidlaw Niels Grabe Maria Pritsch Raffaele Fronza Klaus Hexel Steffen Schmitt Michael Müller-Steinhardt Niels Halama Christoph Domschke Manfred Schmidt Christof von Kalle Florian Schütz Thierry Voet Philipp Beckhove Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients
description	The mechanisms that shape the regulatory T cell repertoire in patients with cancer are not completely understood. Here, the authors observe that, in breast cancer patients, tumor-resident regulatory T cells do not show clonal relationship with their circulating counterpart, but share a common origin with intratumoral antigen-experienced conventional T cells.
format	article
author	Maria Xydia Raheleh Rahbari Eliana Ruggiero Iain Macaulay Maxime Tarabichi Robert Lohmayer Stefan Wilkening Tillmann Michels Daniel Brown Sebastiaan Vanuytven Svetlana Mastitskaya Sean Laidlaw Niels Grabe Maria Pritsch Raffaele Fronza Klaus Hexel Steffen Schmitt Michael Müller-Steinhardt Niels Halama Christoph Domschke Manfred Schmidt Christof von Kalle Florian Schütz Thierry Voet Philipp Beckhove
author_facet	Maria Xydia Raheleh Rahbari Eliana Ruggiero Iain Macaulay Maxime Tarabichi Robert Lohmayer Stefan Wilkening Tillmann Michels Daniel Brown Sebastiaan Vanuytven Svetlana Mastitskaya Sean Laidlaw Niels Grabe Maria Pritsch Raffaele Fronza Klaus Hexel Steffen Schmitt Michael Müller-Steinhardt Niels Halama Christoph Domschke Manfred Schmidt Christof von Kalle Florian Schütz Thierry Voet Philipp Beckhove
author_sort	Maria Xydia
title	Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients
title_short	Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients
title_full	Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients
title_fullStr	Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients
title_full_unstemmed	Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients
title_sort	common clonal origin of conventional t cells and induced regulatory t cells in breast cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/564548dac492461fa165fbbe611c1237
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Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

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