Suboptimal drug exposure leads to selection of different subpopulations of ceftazidime-avibactam-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in a critically ill patient

Suboptimal drug exposure leads to selection of different subpopulations of ceftazidime-avibactam-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in a critically ill patient

Objectives: Ceftazidime-avibactam (CAZ-AVI) is a promising novel agent with activity against carbapenem-resistant Enterobacteriaceae. Here, we describe the dynamic evolution of a Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) infection in a critically ill patient treate...

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Autores principales: Paolo Gaibani, Milo Gatti, Matteo Rinaldi, Cristina Crovara Pesce, Tiziana Lazzarotto, Maddalena Giannella, Donatella Lombardo, Stefano Amadesi, Pierluigi Viale, Federico Pea, Simone Ambretti
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
ceftazidime-avibactam-resistance
PK/PD
critically ill patient
whole-genome sequencing
Infectious and parasitic diseases
RC109-216
Acceso en línea:https://doaj.org/article/56472403412b4437858c06138af240c6
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