Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis

Objective. Interleukin-35 (IL-35), an interleukin-12 (IL-12) cytokine family member, is shown to be a potent immunosuppressive and anti-inflammatory cytokine. Inducible regulatory T cells (Tregs) produce IL-35 that mediates the immune inhibitory function of Tregs. Growing evidence revealed that upre...

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Autores principales:	Yilmaz Hakki, Cakmak M., Ceydilek B., Demir C., Aktas A.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	il-35 hashimoto’s thyroiditis hypothyroidism autoimmunity inflammation Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/5647cb5ca3354f82bef5f876c2164b48
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spelling	oai:doaj.org-article:5647cb5ca3354f82bef5f876c2164b482021-12-02T17:49:19ZRole of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis1336-032910.1515/enr-2016-0009https://doaj.org/article/5647cb5ca3354f82bef5f876c2164b482016-04-01T00:00:00Zhttps://doi.org/10.1515/enr-2016-0009https://doaj.org/toc/1336-0329Objective. Interleukin-35 (IL-35), an interleukin-12 (IL-12) cytokine family member, is shown to be a potent immunosuppressive and anti-inflammatory cytokine. Inducible regulatory T cells (Tregs) produce IL-35 that mediates the immune inhibitory function of Tregs. Growing evidence revealed that upregulation of IL-35 expression may play a critical role in the prevention of autoimmune diseases in various experimental autoimmunity models and vice versa. Hashimoto’s thyroiditis (HT) is considered to be a Treg cell-related autoimmune disease with loss of self-tolerance.Yilmaz HakkiCakmak M.Ceydilek B.Demir C.Aktas A.Sciendoarticleil-35hashimoto’s thyroiditishypothyroidismautoimmunityinflammationDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 50, Iss 2, Pp 55-61 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	il-35 hashimoto’s thyroiditis hypothyroidism autoimmunity inflammation Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	il-35 hashimoto’s thyroiditis hypothyroidism autoimmunity inflammation Diseases of the endocrine glands. Clinical endocrinology RC648-665 Yilmaz Hakki Cakmak M. Ceydilek B. Demir C. Aktas A. Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis
description	Objective. Interleukin-35 (IL-35), an interleukin-12 (IL-12) cytokine family member, is shown to be a potent immunosuppressive and anti-inflammatory cytokine. Inducible regulatory T cells (Tregs) produce IL-35 that mediates the immune inhibitory function of Tregs. Growing evidence revealed that upregulation of IL-35 expression may play a critical role in the prevention of autoimmune diseases in various experimental autoimmunity models and vice versa. Hashimoto’s thyroiditis (HT) is considered to be a Treg cell-related autoimmune disease with loss of self-tolerance.
format	article
author	Yilmaz Hakki Cakmak M. Ceydilek B. Demir C. Aktas A.
author_facet	Yilmaz Hakki Cakmak M. Ceydilek B. Demir C. Aktas A.
author_sort	Yilmaz Hakki
title	Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis
title_short	Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis
title_full	Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis
title_fullStr	Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis
title_full_unstemmed	Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis
title_sort	role of interlekin-35 as a biomarker in patients with newly diagnosed hashimoto’s thyroiditis
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/5647cb5ca3354f82bef5f876c2164b48
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Role of interlekin-35 as a biomarker in patients with newly diagnosed Hashimoto’s thyroiditis

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