Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma

Shinkichi Takamori, 1 Takashi Seto, 1 Mikako Jinnouchi, 2 Taro Oba, 1 Masafumi Yamaguchi, 1 Mitsuhiro Takenoyama 1 1Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, Japan; 2Department of Radiology, National Hospital Organization Kyushu Cancer...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takamori S, Seto T, Jinnouchi M, Oba T, Yamaguchi M, Takenoyama M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	non-small cell lung cancer ros1 crizotinib rapidly destructive coxarthrosis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5647ec1218e14921a67367425c4bdbce
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5647ec1218e14921a67367425c4bdbce
record_format	dspace
spelling	oai:doaj.org-article:5647ec1218e14921a67367425c4bdbce2021-12-02T11:35:35ZRapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma1178-203Xhttps://doaj.org/article/5647ec1218e14921a67367425c4bdbce2020-01-01T00:00:00Zhttps://www.dovepress.com/rapidly-destructive-coxarthrosis-as-a-potential-side-effect-of-crizoti-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203XShinkichi Takamori, 1 Takashi Seto, 1 Mikako Jinnouchi, 2 Taro Oba, 1 Masafumi Yamaguchi, 1 Mitsuhiro Takenoyama 1 1Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, Japan; 2Department of Radiology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, JapanCorrespondence: Takashi SetoDepartment of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, 3-1-1 Notame, Minami-Ku, Fukuoka 811-1395, JapanTel +81 92 541 3231Fax +81 92 551 4585Email setocruise@gmail.comAbstract: A 75-year-old woman was diagnosed with c-ros oncogene 1 (ROS1)-positive lung adenocarcinoma. She was treated with crizotinib 750 mg/day for 4.5 years, with partial tumor response. However, the patient subsequently presented with right hip pain and difficulty in walking. She underwent magnetic resonance imaging (MRI), which detected T2 prolongation in the right femoral bone head, synovial fluid retention, and bone joint fissure narrowing. The patient was diagnosed with rapidly destructive coxarthrosis (RDC) and received a total hip arthroplasty. This represents a rare case of RDC as a potential side effect of crizotinib in a patient with ROS1-positive lung adenocarcinoma. MRI should therefore be recommended in patients receiving crizotinib who experience continuing severe hip pain and difficulty in walking. Further investigations are warranted to elucidate the pathogenesis of RDC associated with crizotinib treatment.Keywords: non-small cell lung cancer, ROS1, crizotinib, rapidly destructive coxarthrosisTakamori SSeto TJinnouchi MOba TYamaguchi MTakenoyama MDove Medical Pressarticlenon-small cell lung cancerros1crizotinibrapidly destructive coxarthrosisTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 16, Pp 17-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-small cell lung cancer ros1 crizotinib rapidly destructive coxarthrosis Therapeutics. Pharmacology RM1-950
spellingShingle	non-small cell lung cancer ros1 crizotinib rapidly destructive coxarthrosis Therapeutics. Pharmacology RM1-950 Takamori S Seto T Jinnouchi M Oba T Yamaguchi M Takenoyama M Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma
description	Shinkichi Takamori, 1 Takashi Seto, 1 Mikako Jinnouchi, 2 Taro Oba, 1 Masafumi Yamaguchi, 1 Mitsuhiro Takenoyama 1 1Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, Japan; 2Department of Radiology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, JapanCorrespondence: Takashi SetoDepartment of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, 3-1-1 Notame, Minami-Ku, Fukuoka 811-1395, JapanTel +81 92 541 3231Fax +81 92 551 4585Email setocruise@gmail.comAbstract: A 75-year-old woman was diagnosed with c-ros oncogene 1 (ROS1)-positive lung adenocarcinoma. She was treated with crizotinib 750 mg/day for 4.5 years, with partial tumor response. However, the patient subsequently presented with right hip pain and difficulty in walking. She underwent magnetic resonance imaging (MRI), which detected T2 prolongation in the right femoral bone head, synovial fluid retention, and bone joint fissure narrowing. The patient was diagnosed with rapidly destructive coxarthrosis (RDC) and received a total hip arthroplasty. This represents a rare case of RDC as a potential side effect of crizotinib in a patient with ROS1-positive lung adenocarcinoma. MRI should therefore be recommended in patients receiving crizotinib who experience continuing severe hip pain and difficulty in walking. Further investigations are warranted to elucidate the pathogenesis of RDC associated with crizotinib treatment.Keywords: non-small cell lung cancer, ROS1, crizotinib, rapidly destructive coxarthrosis
format	article
author	Takamori S Seto T Jinnouchi M Oba T Yamaguchi M Takenoyama M
author_facet	Takamori S Seto T Jinnouchi M Oba T Yamaguchi M Takenoyama M
author_sort	Takamori S
title	Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma
title_short	Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma
title_full	Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma
title_fullStr	Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma
title_full_unstemmed	Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma
title_sort	rapidly destructive coxarthrosis as a potential side effect of crizotinib in a patient with ros1-positive lung adenocarcinoma
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5647ec1218e14921a67367425c4bdbce
work_keys_str_mv	AT takamoris rapidlydestructivecoxarthrosisasapotentialsideeffectofcrizotinibinapatientwithros1positivelungadenocarcinoma AT setot rapidlydestructivecoxarthrosisasapotentialsideeffectofcrizotinibinapatientwithros1positivelungadenocarcinoma AT jinnouchim rapidlydestructivecoxarthrosisasapotentialsideeffectofcrizotinibinapatientwithros1positivelungadenocarcinoma AT obat rapidlydestructivecoxarthrosisasapotentialsideeffectofcrizotinibinapatientwithros1positivelungadenocarcinoma AT yamaguchim rapidlydestructivecoxarthrosisasapotentialsideeffectofcrizotinibinapatientwithros1positivelungadenocarcinoma AT takenoyamam rapidlydestructivecoxarthrosisasapotentialsideeffectofcrizotinibinapatientwithros1positivelungadenocarcinoma
_version_	1718395820314722304

Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma

Ejemplares similares