Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A

Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A

Extracellular vesicles are released from cells and permit communication between different cell types. Here, the authors identify that the FDA approved antibiotic sulfisoxazole, can block the release of these vesicles in breast cancer cells resulting in reduced cell growth in vitro and in vivo.

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Detalles Bibliográficos
Autores principales: Eun-Ju Im, Chan-Hyeong Lee, Pyong-Gon Moon, Gunassekaran Gowri Rangaswamy, Byungheon Lee, Jae Man Lee, Jae-Chul Lee, Jun-Goo Jee, Jong-Sup Bae, Taeg-Kyu Kwon, Keon-Wook Kang, Myeong-Seon Jeong, Joo-Eun Lee, Hyun-Suk Jung, Hyun-Joo Ro, Sangmi Jun, Wonku Kang, Seung-Yong Seo, Young-Eun Cho, Byoung-Joon Song, Moon-Chang Baek
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/564a9fb0ea3542299cb37cacb0869df3
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Descripción
Sumario:Extracellular vesicles are released from cells and permit communication between different cell types. Here, the authors identify that the FDA approved antibiotic sulfisoxazole, can block the release of these vesicles in breast cancer cells resulting in reduced cell growth in vitro and in vivo.

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