Jintiange Capsule May Have a Positive Effect on Pain Relief and Functional Activity in Patients with Knee Osteoarthritis: A Meta-Analysis of Randomized Trials

Background. Knee osteoarthritis (KOA) occurs frequently in the elderly and causes pain, especially when they walk. Traditional Chinese medicine treatment is effective in releasing knee osteoarthritis. Jintiange (JTG) capsule is widely used in treating knee osteoarthritis, but its clinical effects su...

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Autores principales:	Zijian Yan, Jiahao Li, Xiaoming He, Zifeng Wang, Yinuo Fan, Jiacong Xiao, Liang Mo, Sheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/564adeb918974f50be512690a1d06ab4
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spelling	oai:doaj.org-article:564adeb918974f50be512690a1d06ab42021-11-15T01:19:37ZJintiange Capsule May Have a Positive Effect on Pain Relief and Functional Activity in Patients with Knee Osteoarthritis: A Meta-Analysis of Randomized Trials1741-428810.1155/2021/7908429https://doaj.org/article/564adeb918974f50be512690a1d06ab42021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7908429https://doaj.org/toc/1741-4288Background. Knee osteoarthritis (KOA) occurs frequently in the elderly and causes pain, especially when they walk. Traditional Chinese medicine treatment is effective in releasing knee osteoarthritis. Jintiange (JTG) capsule is widely used in treating knee osteoarthritis, but its clinical effects such as pain relief are still unclear. This meta-analysis aims to evaluate the clinical results systematically and negative effects of JTG capsule in patients with knee osteoarthritis. Methods. A meta-analysis of clinical randomized controlled trials (RCTs) on JTG capsule treatment was carried out in KOA patients. The search time was from the establishment of the database to May 2021. The database included PubMed, Cochrane Library, EMBASE, Web of Science database, Chinese Biomedical database (CBM), Chinese VIP information, China National Knowledge Infrastructure (CNKI), and WanFang database. The outcome indicators were extracted from the included literature and analyzed, and the risk of bias was assessed through Cochrane Handbook 5.0.1. Results. Twenty-two articles analyzed in this study involved 1887 patients. JTG capsule used alone or used with other interventions affects total effective rate significantly (RR: 1.19; 95% Cl: 1.11, 1.29; P=0.045), VAS score (SMD: −0.74; 95% Cl: −0.90, −0.59; P≤0.001), WOMAC score (SMD: −0.77; 95% Cl: −0.96, −0.59; P≤0.001), and Lequesne score (SMD: −0.82; 95% Cl: −1.02, −0.61; P=0.010). Conclusion. Our current evidence indicated that JTG capsule may release the pain of KOA patients and improve their functional activity. However, considering the unsatisfactory quality of the included trials, more high-quality trials are needed to prove this issue.Zijian YanJiahao LiXiaoming HeZifeng WangYinuo FanJiacong XiaoLiang MoSheng WangHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Zijian Yan Jiahao Li Xiaoming He Zifeng Wang Yinuo Fan Jiacong Xiao Liang Mo Sheng Wang Jintiange Capsule May Have a Positive Effect on Pain Relief and Functional Activity in Patients with Knee Osteoarthritis: A Meta-Analysis of Randomized Trials
description	Background. Knee osteoarthritis (KOA) occurs frequently in the elderly and causes pain, especially when they walk. Traditional Chinese medicine treatment is effective in releasing knee osteoarthritis. Jintiange (JTG) capsule is widely used in treating knee osteoarthritis, but its clinical effects such as pain relief are still unclear. This meta-analysis aims to evaluate the clinical results systematically and negative effects of JTG capsule in patients with knee osteoarthritis. Methods. A meta-analysis of clinical randomized controlled trials (RCTs) on JTG capsule treatment was carried out in KOA patients. The search time was from the establishment of the database to May 2021. The database included PubMed, Cochrane Library, EMBASE, Web of Science database, Chinese Biomedical database (CBM), Chinese VIP information, China National Knowledge Infrastructure (CNKI), and WanFang database. The outcome indicators were extracted from the included literature and analyzed, and the risk of bias was assessed through Cochrane Handbook 5.0.1. Results. Twenty-two articles analyzed in this study involved 1887 patients. JTG capsule used alone or used with other interventions affects total effective rate significantly (RR: 1.19; 95% Cl: 1.11, 1.29; P=0.045), VAS score (SMD: −0.74; 95% Cl: −0.90, −0.59; P≤0.001), WOMAC score (SMD: −0.77; 95% Cl: −0.96, −0.59; P≤0.001), and Lequesne score (SMD: −0.82; 95% Cl: −1.02, −0.61; P=0.010). Conclusion. Our current evidence indicated that JTG capsule may release the pain of KOA patients and improve their functional activity. However, considering the unsatisfactory quality of the included trials, more high-quality trials are needed to prove this issue.
format	article
author	Zijian Yan Jiahao Li Xiaoming He Zifeng Wang Yinuo Fan Jiacong Xiao Liang Mo Sheng Wang
author_facet	Zijian Yan Jiahao Li Xiaoming He Zifeng Wang Yinuo Fan Jiacong Xiao Liang Mo Sheng Wang
author_sort	Zijian Yan
title	Jintiange Capsule May Have a Positive Effect on Pain Relief and Functional Activity in Patients with Knee Osteoarthritis: A Meta-Analysis of Randomized Trials
title_short	Jintiange Capsule May Have a Positive Effect on Pain Relief and Functional Activity in Patients with Knee Osteoarthritis: A Meta-Analysis of Randomized Trials
title_full	Jintiange Capsule May Have a Positive Effect on Pain Relief and Functional Activity in Patients with Knee Osteoarthritis: A Meta-Analysis of Randomized Trials
title_fullStr	Jintiange Capsule May Have a Positive Effect on Pain Relief and Functional Activity in Patients with Knee Osteoarthritis: A Meta-Analysis of Randomized Trials
title_full_unstemmed	Jintiange Capsule May Have a Positive Effect on Pain Relief and Functional Activity in Patients with Knee Osteoarthritis: A Meta-Analysis of Randomized Trials
title_sort	jintiange capsule may have a positive effect on pain relief and functional activity in patients with knee osteoarthritis: a meta-analysis of randomized trials
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/564adeb918974f50be512690a1d06ab4
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Jintiange Capsule May Have a Positive Effect on Pain Relief and Functional Activity in Patients with Knee Osteoarthritis: A Meta-Analysis of Randomized Trials

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