Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

During wound induced hair follicle neogenesis (WIHN), stem cells regenerate hair follicles but how this arises is unclear. Here, the authors show that self-noncoding dsRNA activates the antiviral receptor TLR3 to induce intrinsic retinoic acid, which stimulates WIHN in mice, and in isolated human ke...

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Autores principales: Dongwon Kim, Ruosi Chen, Mary Sheu, Noori Kim, Sooah Kim, Nasif Islam, Eric M. Wier, Gaofeng Wang, Ang Li, Angela Park, Wooyang Son, Benjamin Evans, Victoria Yu, Vicky P. Prizmic, Eugene Oh, Zixiao Wang, Jianshi Yu, Weiliang Huang, Nathan K. Archer, Zhiqi Hu, Nashay Clemetson, Amanda M. Nelson, Anna Chien, Ginette A. Okoye, Lloyd S. Miller, Gabriel Ghiaur, Sewon Kang, Jace W. Jones, Maureen A. Kane, Luis A. Garza
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/564f599801064b9c89f41e9691fc9196
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spelling oai:doaj.org-article:564f599801064b9c89f41e9691fc91962021-12-02T14:35:56ZNoncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR310.1038/s41467-019-10811-y2041-1723https://doaj.org/article/564f599801064b9c89f41e9691fc91962019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10811-yhttps://doaj.org/toc/2041-1723During wound induced hair follicle neogenesis (WIHN), stem cells regenerate hair follicles but how this arises is unclear. Here, the authors show that self-noncoding dsRNA activates the antiviral receptor TLR3 to induce intrinsic retinoic acid, which stimulates WIHN in mice, and in isolated human keratinocyte cells.Dongwon KimRuosi ChenMary SheuNoori KimSooah KimNasif IslamEric M. WierGaofeng WangAng LiAngela ParkWooyang SonBenjamin EvansVictoria YuVicky P. PrizmicEugene OhZixiao WangJianshi YuWeiliang HuangNathan K. ArcherZhiqi HuNashay ClemetsonAmanda M. NelsonAnna ChienGinette A. OkoyeLloyd S. MillerGabriel GhiaurSewon KangJace W. JonesMaureen A. KaneLuis A. GarzaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dongwon Kim
Ruosi Chen
Mary Sheu
Noori Kim
Sooah Kim
Nasif Islam
Eric M. Wier
Gaofeng Wang
Ang Li
Angela Park
Wooyang Son
Benjamin Evans
Victoria Yu
Vicky P. Prizmic
Eugene Oh
Zixiao Wang
Jianshi Yu
Weiliang Huang
Nathan K. Archer
Zhiqi Hu
Nashay Clemetson
Amanda M. Nelson
Anna Chien
Ginette A. Okoye
Lloyd S. Miller
Gabriel Ghiaur
Sewon Kang
Jace W. Jones
Maureen A. Kane
Luis A. Garza
Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
description During wound induced hair follicle neogenesis (WIHN), stem cells regenerate hair follicles but how this arises is unclear. Here, the authors show that self-noncoding dsRNA activates the antiviral receptor TLR3 to induce intrinsic retinoic acid, which stimulates WIHN in mice, and in isolated human keratinocyte cells.
format article
author Dongwon Kim
Ruosi Chen
Mary Sheu
Noori Kim
Sooah Kim
Nasif Islam
Eric M. Wier
Gaofeng Wang
Ang Li
Angela Park
Wooyang Son
Benjamin Evans
Victoria Yu
Vicky P. Prizmic
Eugene Oh
Zixiao Wang
Jianshi Yu
Weiliang Huang
Nathan K. Archer
Zhiqi Hu
Nashay Clemetson
Amanda M. Nelson
Anna Chien
Ginette A. Okoye
Lloyd S. Miller
Gabriel Ghiaur
Sewon Kang
Jace W. Jones
Maureen A. Kane
Luis A. Garza
author_facet Dongwon Kim
Ruosi Chen
Mary Sheu
Noori Kim
Sooah Kim
Nasif Islam
Eric M. Wier
Gaofeng Wang
Ang Li
Angela Park
Wooyang Son
Benjamin Evans
Victoria Yu
Vicky P. Prizmic
Eugene Oh
Zixiao Wang
Jianshi Yu
Weiliang Huang
Nathan K. Archer
Zhiqi Hu
Nashay Clemetson
Amanda M. Nelson
Anna Chien
Ginette A. Okoye
Lloyd S. Miller
Gabriel Ghiaur
Sewon Kang
Jace W. Jones
Maureen A. Kane
Luis A. Garza
author_sort Dongwon Kim
title Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
title_short Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
title_full Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
title_fullStr Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
title_full_unstemmed Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
title_sort noncoding dsrna induces retinoic acid synthesis to stimulate hair follicle regeneration via tlr3
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/564f599801064b9c89f41e9691fc9196
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