Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy

Weiwei Wang,1 Junting Fan,2 Guang Zhu,1 Jing Wang,1 Yumei Qian,1 Hongxia Li,1 Jianming Ju,3 Lingling Shan1 1Institute of Pharmaceutical Biotechnology, School of Biology and Food Engineering, Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes, Suzhou University, Su...

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Autores principales:	Wang W, Fan J, Zhu G, Wang J, Qian Y, Li H, Ju J, Shan L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	targeted prodrug nanoplatform nir imaging chemotherapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5650312642934a779ca154913f3eb468
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spelling	oai:doaj.org-article:5650312642934a779ca154913f3eb4682021-12-02T09:05:22ZTargeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy1178-2013https://doaj.org/article/5650312642934a779ca154913f3eb4682020-04-01T00:00:00Zhttps://www.dovepress.com/targeted-prodrug-based-self-assembled-nanoparticles-for-cancer-therapy-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Weiwei Wang,1 Junting Fan,2 Guang Zhu,1 Jing Wang,1 Yumei Qian,1 Hongxia Li,1 Jianming Ju,3 Lingling Shan1 1Institute of Pharmaceutical Biotechnology, School of Biology and Food Engineering, Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes, Suzhou University, Suzhou 234000, People’s Republic of China; 2Department of Pharmaceutical Analysis, School of Pharmacy, Nanjing Medical University, Nanjing 211166, People’s Republic of China; 3Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, People’s Republic of ChinaCorrespondence: Lingling Shan; Junting Fan Email ntlinger-300@163.com; Juntingfan@njmu.edu.cnBackground: Targeted prodrug has various applications as drug formulation for tumor therapy. Therefore, amphoteric small-molecule prodrug combined with nanoscale characteristics for the self-assembly of the nano-drug delivery system (DDS) is a highly interesting research topic.Methods and Results: In this study, we developed a prodrug self-assembled nanoplatform, 2-glucosamine-fluorescein-5(6)-isothiocyanate-glutamic acid-paclitaxel (2DA-FITC-PTX NPs) by integration of targeted small molecule and nano-DDS with regular structure and perfect targeting ability. 2-glucosamine (DA) and paclitaxel were conjugated as the targeted ligand and anti-tumor chemotherapy drug by amino acid group. 2-DA molecular structure can enhance the targeting ability of prodrug-based 2DA-FITC-PTX NPs and prolong retention time, thereby reducing the toxicity of normal cell/tissue. The fluorescent dye FITC or near-infrared fluorescent dye ICG in prodrug-based DDS was attractive for in vivo optical imaging to study the behavior of 2DA-FITC-PTX NPs. In vitro and in vivo results proved that 2DA-FITC-PTX NPs exhibited excellent targeting ability, anticancer activity, and weak side effects.Conclusion: This work demonstrates a new combination of nanomaterials for chemotherapy and may promote prodrug-based DDS clinical applications in the future.Keywords: targeted prodrug, nanoplatform, NIR imaging, chemotherapyWang WFan JZhu GWang JQian YLi HJu JShan LDove Medical Pressarticletargeted prodrugnanoplatformnir imagingchemotherapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 2921-2933 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	targeted prodrug nanoplatform nir imaging chemotherapy Medicine (General) R5-920
spellingShingle	targeted prodrug nanoplatform nir imaging chemotherapy Medicine (General) R5-920 Wang W Fan J Zhu G Wang J Qian Y Li H Ju J Shan L Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy
description	Weiwei Wang,1 Junting Fan,2 Guang Zhu,1 Jing Wang,1 Yumei Qian,1 Hongxia Li,1 Jianming Ju,3 Lingling Shan1 1Institute of Pharmaceutical Biotechnology, School of Biology and Food Engineering, Key Laboratory of Spin Electron and Nanomaterials of Anhui Higher Education Institutes, Suzhou University, Suzhou 234000, People’s Republic of China; 2Department of Pharmaceutical Analysis, School of Pharmacy, Nanjing Medical University, Nanjing 211166, People’s Republic of China; 3Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, People’s Republic of ChinaCorrespondence: Lingling Shan; Junting Fan Email ntlinger-300@163.com; Juntingfan@njmu.edu.cnBackground: Targeted prodrug has various applications as drug formulation for tumor therapy. Therefore, amphoteric small-molecule prodrug combined with nanoscale characteristics for the self-assembly of the nano-drug delivery system (DDS) is a highly interesting research topic.Methods and Results: In this study, we developed a prodrug self-assembled nanoplatform, 2-glucosamine-fluorescein-5(6)-isothiocyanate-glutamic acid-paclitaxel (2DA-FITC-PTX NPs) by integration of targeted small molecule and nano-DDS with regular structure and perfect targeting ability. 2-glucosamine (DA) and paclitaxel were conjugated as the targeted ligand and anti-tumor chemotherapy drug by amino acid group. 2-DA molecular structure can enhance the targeting ability of prodrug-based 2DA-FITC-PTX NPs and prolong retention time, thereby reducing the toxicity of normal cell/tissue. The fluorescent dye FITC or near-infrared fluorescent dye ICG in prodrug-based DDS was attractive for in vivo optical imaging to study the behavior of 2DA-FITC-PTX NPs. In vitro and in vivo results proved that 2DA-FITC-PTX NPs exhibited excellent targeting ability, anticancer activity, and weak side effects.Conclusion: This work demonstrates a new combination of nanomaterials for chemotherapy and may promote prodrug-based DDS clinical applications in the future.Keywords: targeted prodrug, nanoplatform, NIR imaging, chemotherapy
format	article
author	Wang W Fan J Zhu G Wang J Qian Y Li H Ju J Shan L
author_facet	Wang W Fan J Zhu G Wang J Qian Y Li H Ju J Shan L
author_sort	Wang W
title	Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy
title_short	Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy
title_full	Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy
title_fullStr	Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy
title_full_unstemmed	Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy
title_sort	targeted prodrug-based self-assembled nanoparticles for cancer therapy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5650312642934a779ca154913f3eb468
work_keys_str_mv	AT wangw targetedprodrugbasedselfassemblednanoparticlesforcancertherapy AT fanj targetedprodrugbasedselfassemblednanoparticlesforcancertherapy AT zhug targetedprodrugbasedselfassemblednanoparticlesforcancertherapy AT wangj targetedprodrugbasedselfassemblednanoparticlesforcancertherapy AT qiany targetedprodrugbasedselfassemblednanoparticlesforcancertherapy AT lih targetedprodrugbasedselfassemblednanoparticlesforcancertherapy AT juj targetedprodrugbasedselfassemblednanoparticlesforcancertherapy AT shanl targetedprodrugbasedselfassemblednanoparticlesforcancertherapy
_version_	1718398243980705792

Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy

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