Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts

Abstract Vector-borne pathogens establish systemic infections in host tissues to maximize transmission to arthropod vectors. Co-feeding transmission occurs when the pathogen is transferred between infected and naive vectors that feed in close spatiotemporal proximity on a host that has not yet devel...

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Autores principales:	Alessandro Belli, Anouk Sarr, Olivier Rais, Ryan O. M. Rego, Maarten J. Voordouw
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56527dc79fc446fd8d5c6a4b0c25648f
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spelling	oai:doaj.org-article:56527dc79fc446fd8d5c6a4b0c25648f2021-12-02T12:32:58ZTicks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts10.1038/s41598-017-05231-12045-2322https://doaj.org/article/56527dc79fc446fd8d5c6a4b0c25648f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05231-1https://doaj.org/toc/2045-2322Abstract Vector-borne pathogens establish systemic infections in host tissues to maximize transmission to arthropod vectors. Co-feeding transmission occurs when the pathogen is transferred between infected and naive vectors that feed in close spatiotemporal proximity on a host that has not yet developed a systemic infection. Borrelia afzelii is a tick-borne spirochete bacterium that causes Lyme borreliosis (LB) and is capable of co-feeding transmission. Whether ticks that acquire LB pathogens via co-feeding are actually infectious to vertebrate hosts has never been tested. We created nymphs that had been experimentally infected as larvae with B. afzelii via co-feeding or systemic transmission, and compared their performance over one complete LB life cycle. Co-feeding nymphs had a spirochete load that was 26 times lower than systemic nymphs but both nymphs were highly infectious to mice (i.e., probability of nymph-to-host transmission of B. afzelii was ~100%). The mode of transmission had no effect on the other infection phenotypes of the LB life cycle. Ticks that acquire B. afzelii via co-feeding transmission are highly infectious to rodents, and the resulting rodent infection is highly infectious to larval ticks. This is the first study to show that B. afzelii can use co-feeding transmission to complete its life cycle.Alessandro BelliAnouk SarrOlivier RaisRyan O. M. RegoMaarten J. VoordouwNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alessandro Belli Anouk Sarr Olivier Rais Ryan O. M. Rego Maarten J. Voordouw Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts
description	Abstract Vector-borne pathogens establish systemic infections in host tissues to maximize transmission to arthropod vectors. Co-feeding transmission occurs when the pathogen is transferred between infected and naive vectors that feed in close spatiotemporal proximity on a host that has not yet developed a systemic infection. Borrelia afzelii is a tick-borne spirochete bacterium that causes Lyme borreliosis (LB) and is capable of co-feeding transmission. Whether ticks that acquire LB pathogens via co-feeding are actually infectious to vertebrate hosts has never been tested. We created nymphs that had been experimentally infected as larvae with B. afzelii via co-feeding or systemic transmission, and compared their performance over one complete LB life cycle. Co-feeding nymphs had a spirochete load that was 26 times lower than systemic nymphs but both nymphs were highly infectious to mice (i.e., probability of nymph-to-host transmission of B. afzelii was ~100%). The mode of transmission had no effect on the other infection phenotypes of the LB life cycle. Ticks that acquire B. afzelii via co-feeding transmission are highly infectious to rodents, and the resulting rodent infection is highly infectious to larval ticks. This is the first study to show that B. afzelii can use co-feeding transmission to complete its life cycle.
format	article
author	Alessandro Belli Anouk Sarr Olivier Rais Ryan O. M. Rego Maarten J. Voordouw
author_facet	Alessandro Belli Anouk Sarr Olivier Rais Ryan O. M. Rego Maarten J. Voordouw
author_sort	Alessandro Belli
title	Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts
title_short	Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts
title_full	Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts
title_fullStr	Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts
title_full_unstemmed	Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts
title_sort	ticks infected via co-feeding transmission can transmit lyme borreliosis to vertebrate hosts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/56527dc79fc446fd8d5c6a4b0c25648f
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Ticks infected via co-feeding transmission can transmit Lyme borreliosis to vertebrate hosts

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