Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study

Abstract The association of fasting glucose with the risk of death according to sex and age remains unclear, and insufficient information is available on sex- and age-specific glucose concentrations within ethnic groups. This study analyzed a sample of 12,455,361 Korean adults who participated in he...

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Autores principales:	Sang-Wook Yi, Sangkyu Park, Yong-ho Lee, Hyang-Jeong Park, Beverley Balkau, Jee-Jeon Yi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5652934ca6664f7ab08985f3f0278757
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spelling	oai:doaj.org-article:5652934ca6664f7ab08985f3f02787572021-12-02T11:52:31ZAssociation between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study10.1038/s41598-017-08498-62045-2322https://doaj.org/article/5652934ca6664f7ab08985f3f02787572017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08498-6https://doaj.org/toc/2045-2322Abstract The association of fasting glucose with the risk of death according to sex and age remains unclear, and insufficient information is available on sex- and age-specific glucose concentrations within ethnic groups. This study analyzed a sample of 12,455,361 Korean adults who participated in health examinations during 2001–2004, and were followed up until 2013. Men had 3.0 mg/dL (0.167 mmol/L) higher mean glucose concentrations than women (94.7 vs. 91.7 mg/dL), although women over 73 years had higher levels. For glucose levels of 100–199 mg/dL, each 18 mg/dL (1 mmol/L) increase in fasting glucose increased mortality by 13% (HR = 1.13, [95% CI 1.12 to 1.13], p < 0.001). In individuals with fasting glucose levels of 100–125 mg/dL, each 18 mg/dL increase in fasting glucose was associated with a 30% increase in the risk for mortality (1.30, [1.18 to 1.43]) in those aged 18–34 years, a 32% increase (1.32, [1.26 to 1.39]) in those aged 35–44 years, and a 10% increase (1.10, [1.02 to 1.19]) in those aged 75–99 years. The fasting glucose levels associated with the lowest mortality were 80–94 mg/dL regardless of sex and age. Prediabetes (100–125 mg/dL) was associated with higher mortality. The associations of hyperglycemia with mortality were stronger at younger ages.Sang-Wook YiSangkyu ParkYong-ho LeeHyang-Jeong ParkBeverley BalkauJee-Jeon YiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sang-Wook Yi Sangkyu Park Yong-ho Lee Hyang-Jeong Park Beverley Balkau Jee-Jeon Yi Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study
description	Abstract The association of fasting glucose with the risk of death according to sex and age remains unclear, and insufficient information is available on sex- and age-specific glucose concentrations within ethnic groups. This study analyzed a sample of 12,455,361 Korean adults who participated in health examinations during 2001–2004, and were followed up until 2013. Men had 3.0 mg/dL (0.167 mmol/L) higher mean glucose concentrations than women (94.7 vs. 91.7 mg/dL), although women over 73 years had higher levels. For glucose levels of 100–199 mg/dL, each 18 mg/dL (1 mmol/L) increase in fasting glucose increased mortality by 13% (HR = 1.13, [95% CI 1.12 to 1.13], p < 0.001). In individuals with fasting glucose levels of 100–125 mg/dL, each 18 mg/dL increase in fasting glucose was associated with a 30% increase in the risk for mortality (1.30, [1.18 to 1.43]) in those aged 18–34 years, a 32% increase (1.32, [1.26 to 1.39]) in those aged 35–44 years, and a 10% increase (1.10, [1.02 to 1.19]) in those aged 75–99 years. The fasting glucose levels associated with the lowest mortality were 80–94 mg/dL regardless of sex and age. Prediabetes (100–125 mg/dL) was associated with higher mortality. The associations of hyperglycemia with mortality were stronger at younger ages.
format	article
author	Sang-Wook Yi Sangkyu Park Yong-ho Lee Hyang-Jeong Park Beverley Balkau Jee-Jeon Yi
author_facet	Sang-Wook Yi Sangkyu Park Yong-ho Lee Hyang-Jeong Park Beverley Balkau Jee-Jeon Yi
author_sort	Sang-Wook Yi
title	Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study
title_short	Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study
title_full	Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study
title_fullStr	Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study
title_full_unstemmed	Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study
title_sort	association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5652934ca6664f7ab08985f3f0278757
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Association between fasting glucose and all-cause mortality according to sex and age: a prospective cohort study

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