Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity

ABSTRACT The first years of life are paramount in establishing our endogenous gut microbiota, which is strongly affected by diet and has repeatedly been linked with obesity. However, very few studies have addressed the influence of maternal obesity on infant gut microbiota, which may occur either th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Martin Frederik Laursen, Louise B. B. Andersen, Kim F. Michaelsen, Christian Mølgaard, Ellen Trolle, Martin Iain Bahl, Tine Rask Licht
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	16S rRNA sequencing breastfeeding complementary diet family foods infant gut microbiota maternal obesity Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/565360beb90f44efa9e251fbe3fc5462
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:565360beb90f44efa9e251fbe3fc5462
record_format	dspace
spelling	oai:doaj.org-article:565360beb90f44efa9e251fbe3fc54622021-11-15T15:21:38ZInfant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity10.1128/mSphere.00069-152379-5042https://doaj.org/article/565360beb90f44efa9e251fbe3fc54622016-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00069-15https://doaj.org/toc/2379-5042ABSTRACT The first years of life are paramount in establishing our endogenous gut microbiota, which is strongly affected by diet and has repeatedly been linked with obesity. However, very few studies have addressed the influence of maternal obesity on infant gut microbiota, which may occur either through vertically transmitted microbes or through the dietary habits of the family. Additionally, very little is known about the effect of diet during the complementary feeding period, which is potentially important for gut microbiota development. Here, the gut microbiotas of two different cohorts of infants, born either of a random sample of healthy mothers (n = 114), or of obese mothers (n = 113), were profiled by 16S rRNA amplicon sequencing. Gut microbiota data were compared to breastfeeding patterns and detailed individual dietary recordings to assess effects of the complementary diet. We found that maternal obesity did not influence microbial diversity or specific taxon abundances during the complementary feeding period. Across cohorts, breastfeeding duration and composition of the complementary diet were found to be the major determinants of gut microbiota development. In both cohorts, gut microbial composition and alpha diversity were thus strongly affected by introduction of family foods with high protein and fiber contents. Specifically, intake of meats, cheeses, and Danish rye bread, rich in protein and fiber, were associated with increased alpha diversity. Our results reveal that the transition from early infant feeding to family foods is a major determinant for gut microbiota development. IMPORTANCE The potential influence of maternal obesity on infant gut microbiota may occur either through vertically transmitted microbes or through the dietary habits of the family. Recent studies have suggested that the heritability of obesity may partly be caused by the transmission of “obesogenic” gut microbes. However, the findings presented here suggest that maternal obesity per se does not affect the overall composition of the gut microbiota and its development after introduction of complementary foods. Rather, progression in complementary feeding is found to be the major determinant for gut microbiota establishment. Expanding our understanding of the influence of complementary diet on the development and establishment of the gut microbiota will provide us with the knowledge to tailor a beneficial progression of our intestinal microbial community.Martin Frederik LaursenLouise B. B. AndersenKim F. MichaelsenChristian MølgaardEllen TrolleMartin Iain BahlTine Rask LichtAmerican Society for Microbiologyarticle16S rRNA sequencingbreastfeedingcomplementary dietfamily foodsinfant gut microbiotamaternal obesityMicrobiologyQR1-502ENmSphere, Vol 1, Iss 1 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	16S rRNA sequencing breastfeeding complementary diet family foods infant gut microbiota maternal obesity Microbiology QR1-502
spellingShingle	16S rRNA sequencing breastfeeding complementary diet family foods infant gut microbiota maternal obesity Microbiology QR1-502 Martin Frederik Laursen Louise B. B. Andersen Kim F. Michaelsen Christian Mølgaard Ellen Trolle Martin Iain Bahl Tine Rask Licht Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity
description	ABSTRACT The first years of life are paramount in establishing our endogenous gut microbiota, which is strongly affected by diet and has repeatedly been linked with obesity. However, very few studies have addressed the influence of maternal obesity on infant gut microbiota, which may occur either through vertically transmitted microbes or through the dietary habits of the family. Additionally, very little is known about the effect of diet during the complementary feeding period, which is potentially important for gut microbiota development. Here, the gut microbiotas of two different cohorts of infants, born either of a random sample of healthy mothers (n = 114), or of obese mothers (n = 113), were profiled by 16S rRNA amplicon sequencing. Gut microbiota data were compared to breastfeeding patterns and detailed individual dietary recordings to assess effects of the complementary diet. We found that maternal obesity did not influence microbial diversity or specific taxon abundances during the complementary feeding period. Across cohorts, breastfeeding duration and composition of the complementary diet were found to be the major determinants of gut microbiota development. In both cohorts, gut microbial composition and alpha diversity were thus strongly affected by introduction of family foods with high protein and fiber contents. Specifically, intake of meats, cheeses, and Danish rye bread, rich in protein and fiber, were associated with increased alpha diversity. Our results reveal that the transition from early infant feeding to family foods is a major determinant for gut microbiota development. IMPORTANCE The potential influence of maternal obesity on infant gut microbiota may occur either through vertically transmitted microbes or through the dietary habits of the family. Recent studies have suggested that the heritability of obesity may partly be caused by the transmission of “obesogenic” gut microbes. However, the findings presented here suggest that maternal obesity per se does not affect the overall composition of the gut microbiota and its development after introduction of complementary foods. Rather, progression in complementary feeding is found to be the major determinant for gut microbiota establishment. Expanding our understanding of the influence of complementary diet on the development and establishment of the gut microbiota will provide us with the knowledge to tailor a beneficial progression of our intestinal microbial community.
format	article
author	Martin Frederik Laursen Louise B. B. Andersen Kim F. Michaelsen Christian Mølgaard Ellen Trolle Martin Iain Bahl Tine Rask Licht
author_facet	Martin Frederik Laursen Louise B. B. Andersen Kim F. Michaelsen Christian Mølgaard Ellen Trolle Martin Iain Bahl Tine Rask Licht
author_sort	Martin Frederik Laursen
title	Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity
title_short	Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity
title_full	Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity
title_fullStr	Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity
title_full_unstemmed	Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity
title_sort	infant gut microbiota development is driven by transition to family foods independent of maternal obesity
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/565360beb90f44efa9e251fbe3fc5462
work_keys_str_mv	AT martinfrederiklaursen infantgutmicrobiotadevelopmentisdrivenbytransitiontofamilyfoodsindependentofmaternalobesity AT louisebbandersen infantgutmicrobiotadevelopmentisdrivenbytransitiontofamilyfoodsindependentofmaternalobesity AT kimfmichaelsen infantgutmicrobiotadevelopmentisdrivenbytransitiontofamilyfoodsindependentofmaternalobesity AT christianmølgaard infantgutmicrobiotadevelopmentisdrivenbytransitiontofamilyfoodsindependentofmaternalobesity AT ellentrolle infantgutmicrobiotadevelopmentisdrivenbytransitiontofamilyfoodsindependentofmaternalobesity AT martiniainbahl infantgutmicrobiotadevelopmentisdrivenbytransitiontofamilyfoodsindependentofmaternalobesity AT tinerasklicht infantgutmicrobiotadevelopmentisdrivenbytransitiontofamilyfoodsindependentofmaternalobesity
_version_	1718428128396705792

Infant Gut Microbiota Development Is Driven by Transition to Family Foods Independent of Maternal Obesity

Ejemplares similares