Immune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice.

Few experimental models are available for the study of natural resistance to cancer. One of them is the SR/CR (spontaneous regression/complete resistance) mouse model in which natural resistance to a variety of cancer types appeared to be inherited in SR/CR strains of BALB/c and C57BL/6 mice. The ge...

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Autores principales:	Janne Koch, Jann Hau, Jan Pravsgaard Christensen, Henrik Elvang Jensen, Morten Bagge Hansen, Klaus Rieneck
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/565382844473493aab9a3395b87ff320
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spelling	oai:doaj.org-article:565382844473493aab9a3395b87ff3202021-11-18T07:52:25ZImmune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice.1932-620310.1371/journal.pone.0059995https://doaj.org/article/565382844473493aab9a3395b87ff3202013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555858/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Few experimental models are available for the study of natural resistance to cancer. One of them is the SR/CR (spontaneous regression/complete resistance) mouse model in which natural resistance to a variety of cancer types appeared to be inherited in SR/CR strains of BALB/c and C57BL/6 mice. The genetic, cellular, and molecular effector mechanisms in this model are largely unknown, but cells from the innate immune system may play a significant role. In contrast to previous observations, the cancer resistance was limited to S180 sarcoma cancer cells. We were unable to confirm previous observations of resistance to EL-4 lymphoma cells and J774A.1 monocyte-macrophage cancer cells. The cancer resistance against S180 sarcoma cells could be transferred to susceptible non-resistant BALB/c mice as well as C57BL/6 mice after depletion of both CD4+/CD8+ leukocytes and B-cells from SR/CR mice. In the responding recipient mice, the cancer disappeared gradually following infiltration of a large number of polymorphonuclear granulocytes and remarkably few lymphocytes in the remaining tumor tissues. This study confirmed that the in vivo growth and spread of cancer cells depend on a complex interplay between the cancer cells and the host organism. Here, hereditary components of the immune system, most likely the innate part, played a crucial role in this interplay and lead to resistance to a single experimental cancer type. The fact that leukocytes depleted of both CD4+/CD8+ and B cells from the cancer resistant donor mice could be transferred to inhibit S180 cancer cell growth in susceptible recipient mice support the vision of an efficient and adverse event free immunotherapy in future selected cancer types.Janne KochJann HauJan Pravsgaard ChristensenHenrik Elvang JensenMorten Bagge HansenKlaus RieneckPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59995 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Janne Koch Jann Hau Jan Pravsgaard Christensen Henrik Elvang Jensen Morten Bagge Hansen Klaus Rieneck Immune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice.
description	Few experimental models are available for the study of natural resistance to cancer. One of them is the SR/CR (spontaneous regression/complete resistance) mouse model in which natural resistance to a variety of cancer types appeared to be inherited in SR/CR strains of BALB/c and C57BL/6 mice. The genetic, cellular, and molecular effector mechanisms in this model are largely unknown, but cells from the innate immune system may play a significant role. In contrast to previous observations, the cancer resistance was limited to S180 sarcoma cancer cells. We were unable to confirm previous observations of resistance to EL-4 lymphoma cells and J774A.1 monocyte-macrophage cancer cells. The cancer resistance against S180 sarcoma cells could be transferred to susceptible non-resistant BALB/c mice as well as C57BL/6 mice after depletion of both CD4+/CD8+ leukocytes and B-cells from SR/CR mice. In the responding recipient mice, the cancer disappeared gradually following infiltration of a large number of polymorphonuclear granulocytes and remarkably few lymphocytes in the remaining tumor tissues. This study confirmed that the in vivo growth and spread of cancer cells depend on a complex interplay between the cancer cells and the host organism. Here, hereditary components of the immune system, most likely the innate part, played a crucial role in this interplay and lead to resistance to a single experimental cancer type. The fact that leukocytes depleted of both CD4+/CD8+ and B cells from the cancer resistant donor mice could be transferred to inhibit S180 cancer cell growth in susceptible recipient mice support the vision of an efficient and adverse event free immunotherapy in future selected cancer types.
format	article
author	Janne Koch Jann Hau Jan Pravsgaard Christensen Henrik Elvang Jensen Morten Bagge Hansen Klaus Rieneck
author_facet	Janne Koch Jann Hau Jan Pravsgaard Christensen Henrik Elvang Jensen Morten Bagge Hansen Klaus Rieneck
author_sort	Janne Koch
title	Immune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice.
title_short	Immune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice.
title_full	Immune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice.
title_fullStr	Immune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice.
title_full_unstemmed	Immune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice.
title_sort	immune cells from sr/cr mice induce the regression of established tumors in balb/c and c57bl/6 mice.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/565382844473493aab9a3395b87ff320
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Immune cells from SR/CR mice induce the regression of established tumors in BALB/c and C57BL/6 mice.

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