Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature

Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by a translocation of chromosomes 15 and 17, creating an alternation in the retinoic acid receptor-alpha (RAR-alpha) gene. This leads to excessive medullary production of promyelocytic blasts, which are...

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Autores principales:	Kira MacDougall, Divya Chukkalore, Maryam Rehan, Meena Kashi, Alexander Bershadskiy
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	acute promyelocytic leukemia venous thromboembolism splenic infarct renal infarct ischemic stroke all-transretinoic acid Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/565611e1f0c746648ce094ced13eda14
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spelling	oai:doaj.org-article:565611e1f0c746648ce094ced13eda142021-11-17T14:21:57ZAcute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature2000-966610.1080/20009666.2021.1973657https://doaj.org/article/565611e1f0c746648ce094ced13eda142021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/20009666.2021.1973657https://doaj.org/toc/2000-9666Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by a translocation of chromosomes 15 and 17, creating an alternation in the retinoic acid receptor-alpha (RAR-alpha) gene. This leads to excessive medullary production of promyelocytic blasts, which are frequently associated with the hemorrhagic complications seen in APL. In contrast, APL-associated thrombosis occurs much less frequently and is an underappreciated life-threatening manifestation of the disease. Most thrombotic events occur during induction chemotherapy with all-transretinoic acid and are rarely seen as the initial presentation on APL. Here we report an exceedingly rare case of a patient with recurrent venous and arterial thrombotic events, including deep vein thrombosis, bilateral segmental pulmonary embolism, an ischemic stroke, splenic infarcts, and renal infarcts, later found to have APL. We aim to discuss the most recent understanding of the pathogenesis of APL-associated thrombosis and to summarize the literature of this rare presentation of APL.Kira MacDougallDivya ChukkaloreMaryam RehanMeena KashiAlexander BershadskiyTaylor & Francis Grouparticleacute promyelocytic leukemiavenous thromboembolismsplenic infarctrenal infarctischemic strokeall-transretinoic acidInternal medicineRC31-1245ENJournal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 832-838 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute promyelocytic leukemia venous thromboembolism splenic infarct renal infarct ischemic stroke all-transretinoic acid Internal medicine RC31-1245
spellingShingle	acute promyelocytic leukemia venous thromboembolism splenic infarct renal infarct ischemic stroke all-transretinoic acid Internal medicine RC31-1245 Kira MacDougall Divya Chukkalore Maryam Rehan Meena Kashi Alexander Bershadskiy Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature
description	Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by a translocation of chromosomes 15 and 17, creating an alternation in the retinoic acid receptor-alpha (RAR-alpha) gene. This leads to excessive medullary production of promyelocytic blasts, which are frequently associated with the hemorrhagic complications seen in APL. In contrast, APL-associated thrombosis occurs much less frequently and is an underappreciated life-threatening manifestation of the disease. Most thrombotic events occur during induction chemotherapy with all-transretinoic acid and are rarely seen as the initial presentation on APL. Here we report an exceedingly rare case of a patient with recurrent venous and arterial thrombotic events, including deep vein thrombosis, bilateral segmental pulmonary embolism, an ischemic stroke, splenic infarcts, and renal infarcts, later found to have APL. We aim to discuss the most recent understanding of the pathogenesis of APL-associated thrombosis and to summarize the literature of this rare presentation of APL.
format	article
author	Kira MacDougall Divya Chukkalore Maryam Rehan Meena Kashi Alexander Bershadskiy
author_facet	Kira MacDougall Divya Chukkalore Maryam Rehan Meena Kashi Alexander Bershadskiy
author_sort	Kira MacDougall
title	Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature
title_short	Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature
title_full	Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature
title_fullStr	Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature
title_full_unstemmed	Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature
title_sort	acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/565611e1f0c746648ce094ced13eda14
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Acute promyelocytic leukemia presenting as recurrent venous and arterial thrombotic events: a case report and review of the literature

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