Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids.
Chronic exposure of β-cells to metabolic stresses impairs their function and potentially induces apoptosis. Mitochondria play a central role in coupling glucose metabolism to insulin secretion. However, little is known on mitochondrial responses to specific stresses; i.e. low versus high glucose, sa...
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Autores principales: | Thierry Brun, Pasquale Scarcia, Ning Li, Pascale Gaudet, Dominique Duhamel, Ferdinando Palmieri, Pierre Maechler |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
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Materias: | |
Acceso en línea: | https://doaj.org/article/5659366b00e841df9705bd3d7d86ae48 |
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