Choroidal neovascularization after blunt ocular trauma in angioid streaks

Masaomi Kubota, Takaaki Hayashi, Kota Arai, Hiroshi TsuneokaDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, JapanBackground: Patients with angioid streaks are prone to develop a subretinal hemorrhage after ocular injury, due to fragility of Bruch's membrane.Objec...

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Autores principales:	Kubota M, Hayashi T, Arai K, Tsuneoka H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/565bcd987186412bb55923230d50d914
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spelling	oai:doaj.org-article:565bcd987186412bb55923230d50d9142021-12-02T01:15:46ZChoroidal neovascularization after blunt ocular trauma in angioid streaks1177-54671177-5483https://doaj.org/article/565bcd987186412bb55923230d50d9142013-07-01T00:00:00Zhttp://www.dovepress.com/choroidal-neovascularization-after-blunt-ocular-trauma-in-angioid-stre-a13541https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Masaomi Kubota, Takaaki Hayashi, Kota Arai, Hiroshi TsuneokaDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, JapanBackground: Patients with angioid streaks are prone to develop a subretinal hemorrhage after ocular injury, due to fragility of Bruch's membrane.Objective: The purpose of this study was to report a patient with angioid streaks in whom subfoveal choroidal neovascularization (CNV) developed after blunt ocular trauma.Case report: A 60-year-old man was accidentally struck in the left eye with a crowbar handle while engaged in the demolition of wooden building materials in May 2011 and was initially evaluated at our hospital. Corrected visual acuity was 0.3 in the right and 1.2 in the left eye, and relative afferent pupillary defect was negative. Funduscopy revealed choroidal atrophy around the optic papillae and angioid streaks radiating from around the optic discs in both eyes. In the right eye, there was macular atrophy. In the left eye, there was a subretinal hemorrhage around the macular region. Fluorescein angiography of the left eye showed a blockage due to subretinal hemorrhage and increasing hyperfluorescent spots superior to the fovea, suggestive of extrafoveal CNV. Spectral-domain optical coherence tomography showed macular thinning in the right eye and no obvious abnormalities near the subfoveal region in the left eye. Two months later, the patient noticed decreased visual acuity in the left eye and was reevaluated. Visual acuity had decreased to 0.7, and well-defined CNV, one disc diameter in size, was presenting slightly superior to the macula, including the subfoveal region. Two weeks later, anti-vascular endothelial growth factor (anti-VEGF) antibody (bevacizumab) was injected intravitreally; the CNV then regressed, and visual acuity improved to 1.2.Conclusion: Marked improvement in visual acuity with early treatment has not been reported in angioid streaks with subfoveal CNV after ocular injury. Intravitreal injection of an anti-VEGF antibody should be considered early after the diagnosis of CNV.Keywords: pseudoxanthoma elasticum, subretinal hemorrhage, anti-VEGF therapyKubota MHayashi TArai KTsuneoka HDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1347-1351 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Kubota M Hayashi T Arai K Tsuneoka H Choroidal neovascularization after blunt ocular trauma in angioid streaks
description	Masaomi Kubota, Takaaki Hayashi, Kota Arai, Hiroshi TsuneokaDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, JapanBackground: Patients with angioid streaks are prone to develop a subretinal hemorrhage after ocular injury, due to fragility of Bruch's membrane.Objective: The purpose of this study was to report a patient with angioid streaks in whom subfoveal choroidal neovascularization (CNV) developed after blunt ocular trauma.Case report: A 60-year-old man was accidentally struck in the left eye with a crowbar handle while engaged in the demolition of wooden building materials in May 2011 and was initially evaluated at our hospital. Corrected visual acuity was 0.3 in the right and 1.2 in the left eye, and relative afferent pupillary defect was negative. Funduscopy revealed choroidal atrophy around the optic papillae and angioid streaks radiating from around the optic discs in both eyes. In the right eye, there was macular atrophy. In the left eye, there was a subretinal hemorrhage around the macular region. Fluorescein angiography of the left eye showed a blockage due to subretinal hemorrhage and increasing hyperfluorescent spots superior to the fovea, suggestive of extrafoveal CNV. Spectral-domain optical coherence tomography showed macular thinning in the right eye and no obvious abnormalities near the subfoveal region in the left eye. Two months later, the patient noticed decreased visual acuity in the left eye and was reevaluated. Visual acuity had decreased to 0.7, and well-defined CNV, one disc diameter in size, was presenting slightly superior to the macula, including the subfoveal region. Two weeks later, anti-vascular endothelial growth factor (anti-VEGF) antibody (bevacizumab) was injected intravitreally; the CNV then regressed, and visual acuity improved to 1.2.Conclusion: Marked improvement in visual acuity with early treatment has not been reported in angioid streaks with subfoveal CNV after ocular injury. Intravitreal injection of an anti-VEGF antibody should be considered early after the diagnosis of CNV.Keywords: pseudoxanthoma elasticum, subretinal hemorrhage, anti-VEGF therapy
format	article
author	Kubota M Hayashi T Arai K Tsuneoka H
author_facet	Kubota M Hayashi T Arai K Tsuneoka H
author_sort	Kubota M
title	Choroidal neovascularization after blunt ocular trauma in angioid streaks
title_short	Choroidal neovascularization after blunt ocular trauma in angioid streaks
title_full	Choroidal neovascularization after blunt ocular trauma in angioid streaks
title_fullStr	Choroidal neovascularization after blunt ocular trauma in angioid streaks
title_full_unstemmed	Choroidal neovascularization after blunt ocular trauma in angioid streaks
title_sort	choroidal neovascularization after blunt ocular trauma in angioid streaks
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/565bcd987186412bb55923230d50d914
work_keys_str_mv	AT kubotam choroidalneovascularizationafterbluntoculartraumainangioidstreaks AT hayashit choroidalneovascularizationafterbluntoculartraumainangioidstreaks AT araik choroidalneovascularizationafterbluntoculartraumainangioidstreaks AT tsuneokah choroidalneovascularizationafterbluntoculartraumainangioidstreaks
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Choroidal neovascularization after blunt ocular trauma in angioid streaks

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