Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI

Background: We assessed the 5-year risk of being diagnosed with significant prostate cancer following a low-suspicion biparametric magnetic resonance imaging result. Methods: The study population was derived from a prospective database used to assess the diagnostic accuracy of biparametric magnetic...

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Autores principales:	Karen-Cecilie Kortenbach, Lars Boesen, Vibeke Løgager, Henrik S. Thomsen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biparametric MRI Multiparametric MRI Prostate cancer Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/565fd99dfdc3430f8ceebc5d5fa4c35a
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spelling	oai:doaj.org-article:565fd99dfdc3430f8ceebc5d5fa4c35a2021-12-02T05:02:38ZOutcome of 5-year follow-up in men with negative findings on initial biparametric MRI2405-844010.1016/j.heliyon.2021.e08325https://doaj.org/article/565fd99dfdc3430f8ceebc5d5fa4c35a2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021024282https://doaj.org/toc/2405-8440Background: We assessed the 5-year risk of being diagnosed with significant prostate cancer following a low-suspicion biparametric magnetic resonance imaging result. Methods: The study population was derived from a prospective database used to assess the diagnostic accuracy of biparametric magnetic resonance imaging for significant prostate cancer detection in 1020 biopsy-naïve men. Significant prostate cancer was defined as any core with Gleason grade group ≥3 or a maximum cancerous core length greater than 50% of Gleason grade group 2. A secondary definition of significant prostate cancer was also included: any core with prostate cancer Gleason grade group ≥2. Of the 1020 men, 305 had a low-suspicion biparametric magnetic resonance imaging result (Prostate Imaging Reporting and Data System score of 1 or 2) but four men were excluded from follow-up. Thus, the final study population consisted of 301 men, who were clinically followed-up from inclusion (November 2015 to June 2017) until 1 June 2021. Findings: Overall, 1·7% (5/301) of the study population had significant prostate cancer diagnosed within 5 years (median 1480 days, Interquartile Range (1587–1382)) of their low-suspicion result and corresponding set of biopsies. When the secondary definition of significant prostate cancer was applied, this increased to 5% (15/301) of the study population. Interpretation: The 5-year risk of being diagnosed with significant prostate cancer after a prebiopsy low-suspicion prebiopsy biparametric magnetic resonance imaging result was 1·7%.Karen-Cecilie KortenbachLars BoesenVibeke LøgagerHenrik S. ThomsenElsevierarticleBiparametric MRIMultiparametric MRIProstate cancerScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08325- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biparametric MRI Multiparametric MRI Prostate cancer Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Biparametric MRI Multiparametric MRI Prostate cancer Science (General) Q1-390 Social sciences (General) H1-99 Karen-Cecilie Kortenbach Lars Boesen Vibeke Løgager Henrik S. Thomsen Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI
description	Background: We assessed the 5-year risk of being diagnosed with significant prostate cancer following a low-suspicion biparametric magnetic resonance imaging result. Methods: The study population was derived from a prospective database used to assess the diagnostic accuracy of biparametric magnetic resonance imaging for significant prostate cancer detection in 1020 biopsy-naïve men. Significant prostate cancer was defined as any core with Gleason grade group ≥3 or a maximum cancerous core length greater than 50% of Gleason grade group 2. A secondary definition of significant prostate cancer was also included: any core with prostate cancer Gleason grade group ≥2. Of the 1020 men, 305 had a low-suspicion biparametric magnetic resonance imaging result (Prostate Imaging Reporting and Data System score of 1 or 2) but four men were excluded from follow-up. Thus, the final study population consisted of 301 men, who were clinically followed-up from inclusion (November 2015 to June 2017) until 1 June 2021. Findings: Overall, 1·7% (5/301) of the study population had significant prostate cancer diagnosed within 5 years (median 1480 days, Interquartile Range (1587–1382)) of their low-suspicion result and corresponding set of biopsies. When the secondary definition of significant prostate cancer was applied, this increased to 5% (15/301) of the study population. Interpretation: The 5-year risk of being diagnosed with significant prostate cancer after a prebiopsy low-suspicion prebiopsy biparametric magnetic resonance imaging result was 1·7%.
format	article
author	Karen-Cecilie Kortenbach Lars Boesen Vibeke Løgager Henrik S. Thomsen
author_facet	Karen-Cecilie Kortenbach Lars Boesen Vibeke Løgager Henrik S. Thomsen
author_sort	Karen-Cecilie Kortenbach
title	Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI
title_short	Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI
title_full	Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI
title_fullStr	Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI
title_full_unstemmed	Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI
title_sort	outcome of 5-year follow-up in men with negative findings on initial biparametric mri
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/565fd99dfdc3430f8ceebc5d5fa4c35a
work_keys_str_mv	AT karenceciliekortenbach outcomeof5yearfollowupinmenwithnegativefindingsoninitialbiparametricmri AT larsboesen outcomeof5yearfollowupinmenwithnegativefindingsoninitialbiparametricmri AT vibekeløgager outcomeof5yearfollowupinmenwithnegativefindingsoninitialbiparametricmri AT henriksthomsen outcomeof5yearfollowupinmenwithnegativefindingsoninitialbiparametricmri
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Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI

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